| Literature DB >> 20471997 |
Alberto Zalar1, Maria Ines Figueroa, Beatriz Ruibal-Ares, Patricia Baré, Pedro Cahn, Maria Marta de E de Bracco, Liliana Belmonte.
Abstract
Mucosal surfaces play a major role in human immunodeficiency virus type 1 (HIV-1) transmission and pathogenesis. Since the role of intestinal macrophages as viral reservoirs during chronic HIV-1 infection has not been elucidated, we investigated the effects of successful therapy on intestinal HIV-1 persistence. Intestinal macrophage infection was demonstrated by the expression of p24 antigen by flow cytometry and by the presence of proviral DNA, assessed by PCR. Proviral DNA was detected in duodenal mucosa of HIV-infected patients under treatment with undetectable plasma viral load. These findings confirm that intestinal macrophages can act as viral reservoirs and permit HIV-1 production even after viral suppression following antiretroviral therapy. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20471997 DOI： 10.1016/j.antiviral.2010.05.005
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970