Literature DB >> 20471259

Looking for a 5-HT7 radiotracer for positron emission tomography.

Julien Andriès1, Laëtitia Lemoine, Alice Mouchel-Blaisot, Sandrine Tang, Mathieu Verdurand, Didier Le Bars, Luc Zimmer, Thierry Billard.   

Abstract

In search of a serotonin 5-HT(7) radiotracer for positron emission tomography, we developed 1-[2-[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl 4-fluorobenzoate. After labeling in good yield with fluorine-18 via nitro for fluorine exchange, preliminary biological experiments with autoradiographies failed to evidence any specific 5-HT(7) receptor delineation. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20471259     DOI： 10.1016/j.bmcl.2010.04.076

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  PET tracers for serotonin receptors and their applications.

Authors:  J S Dileep Kumar; J John Mann
Journal:  Cent Nerv Syst Agents Med Chem       Date:  2014

2.  Synthesis and in vitro evaluation of oxindole derivatives as potential radioligands for 5-HT(7) receptor imaging with PET.

Authors:  Matthias M Herth; Balázs Volk; Katalin Pallagi; Lasse Kofoed Bech; Ferenc A Antoni; Gitte M Knudsen; Jesper L Kristensen
Journal:  ACS Chem Neurosci       Date:  2012-08-31       Impact factor: 4.418

Review 3.  5-HT radioligands for human brain imaging with PET and SPECT.

Authors:  Louise M Paterson; Birgitte R Kornum; David J Nutt; Victor W Pike; Gitte M Knudsen
Journal:  Med Res Rev       Date:  2011-06-14       Impact factor: 12.944
  3 in total

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