Literature DB >> 20471231

Novel tuberculosis vaccines on the horizon.

Shreemanta K Parida1, Stefan H E Kaufmann.   

Abstract

Eleven new tuberculosis (TB) vaccines are in various phases of clinical trials. These include subunit vaccines to improve the current vaccine BCG, and recombinant BCG to substitute for BCG, both given pre-exposure to prevent active disease. A plethora of potential candidates have reached various stages of the pre-clinical development pipeline, some ready to enter Phase I clinical trial soon. A boost vaccine to top up the immunity of existing BCG is on the horizon and will have to suffice until a better candidate to replace BCG is ready. The live mutants of Mycobacterium tuberculosis show great promise, but face a myriad of regulatory challenges. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20471231     DOI： 10.1016/j.coi.2010.04.006

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  26 in total

1.  Vaccines displaying mycobacterial proteins on biopolyester beads stimulate cellular immunity and induce protection against tuberculosis.

Authors:  Natalie A Parlane; Katrin Grage; Jun Mifune; Randall J Basaraba; D Neil Wedlock; Bernd H A Rehm; Bryce M Buddle
Journal:  Clin Vaccine Immunol       Date:  2011-11-09

2.  Bacillus Calmette-Guérin vaccination using a microneedle patch.

Authors:  Yasuhiro Hiraishi; Subhadra Nandakumar; Seong-O Choi; Jeong Woo Lee; Yeu-Chun Kim; James E Posey; Suraj B Sable; Mark R Prausnitz
Journal:  Vaccine       Date:  2011-01-28       Impact factor: 3.641

3.  Protection against Mycobacterium leprae infection by the ID83/GLA-SE and ID93/GLA-SE vaccines developed for tuberculosis.

Authors:  Malcolm S Duthie; Rhea N Coler; John D Laurance; Lucas H Sampaio; Regiane M Oliveira; Ana Lucia M Sousa; Mariane M A Stefani; Yumi Maeda; Masanori Matsuoka; Masahiko Makino; Steven G Reed
Journal:  Infect Immun       Date:  2014-07-14       Impact factor: 3.441

4.  Vaccines and future global health needs.

Authors:  G J V Nossal
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2011-10-12       Impact factor: 6.237

5.  Vaccines, reverse vaccinology, and bacterial pathogenesis.

Authors:  Isabel Delany; Rino Rappuoli; Kate L Seib
Journal:  Cold Spring Harb Perspect Med       Date:  2013-05-01       Impact factor: 6.915

6.  Production of a particulate hepatitis C vaccine candidate by an engineered Lactococcus lactis strain.

Authors:  Natalie A Parlane; Katrin Grage; Jason W Lee; Bryce M Buddle; Michel Denis; Bernd H A Rehm
Journal:  Appl Environ Microbiol       Date:  2011-10-07       Impact factor: 4.792

7.  The importance of adjuvant formulation in the development of a tuberculosis vaccine.

Authors:  Susan L Baldwin; Sylvie Bertholet; Valerie A Reese; Lance K Ching; Steven G Reed; Rhea N Coler
Journal:  J Immunol       Date:  2012-01-30       Impact factor: 5.422

8.  BCG vaccination in patients with severe combined immunodeficiency: complications, risks, and vaccination policies.

Authors:  Beatriz E Marciano; Chiung-Yu Huang; Gyan Joshi; Nima Rezaei; Beatriz Costa Carvalho; Zoe Allwood; Aydan Ikinciogullari; Shereen M Reda; Andrew Gennery; Vojtech Thon; Francisco Espinosa-Rosales; Waleed Al-Herz; Oscar Porras; Anna Shcherbina; Anna Szaflarska; Şebnem Kiliç; Jose L Franco; Andrea C Gómez Raccio; Persio Roxo; Isabel Esteves; Nermeen Galal; Anete Sevciovic Grumach; Salem Al-Tamemi; Alisan Yildiran; Julio C Orellana; Masafumi Yamada; Tomohiro Morio; Diana Liberatore; Yoshitoshi Ohtsuka; Yu-Lung Lau; Ryuta Nishikomori; Carlos Torres-Lozano; Juliana T L Mazzucchelli; Maria M S Vilela; Fabiola S Tavares; Luciana Cunha; Jorge A Pinto; Sara E Espinosa-Padilla; Leticia Hernandez-Nieto; Reem A Elfeky; Tadashi Ariga; Heike Toshio; Figen Dogu; Funda Cipe; Renata Formankova; M Enriqueta Nuñez-Nuñez; Liliana Bezrodnik; Jose Gonçalo Marques; María I Pereira; Viviana Listello; Mary A Slatter; Zohreh Nademi; Danuta Kowalczyk; Thomas A Fleisher; Graham Davies; Bénédicte Neven; Sergio D Rosenzweig
Journal:  J Allergy Clin Immunol       Date:  2014-04       Impact factor: 10.793

9.  Immunogenic Properties of Lactobacillus plantarum Producing Surface-Displayed Mycobacterium tuberculosis Antigens.

Authors:  Katarzyna Kuczkowska; Charlotte R Kleiveland; Rajna Minic; Lars F Moen; Lise Øverland; Rannei Tjåland; Harald Carlsen; Tor Lea; Geir Mathiesen; Vincent G H Eijsink
Journal:  Appl Environ Microbiol       Date:  2016-12-30       Impact factor: 4.792

10.  Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis.

Authors:  Nele Festjens; Pieter Bogaert; Anjana Batni; Erica Houthuys; Evelyn Plets; Dieter Vanderschaeghe; Bram Laukens; Bob Asselbergh; Eef Parthoens; Riet De Rycke; Monique A Willart; Peggy Jacques; Dirk Elewaut; Peter Brouckaert; Bart N Lambrecht; Kris Huygen; Nico Callewaert
Journal:  EMBO Mol Med       Date:  2011-02-16       Impact factor: 12.137
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