Literature DB >> 20471101

5-HT2A receptor gene polymorphisms in Croatian subjects with autistic disorder.

Dubravka Hranilovic1, Sofia Blazevic, Marina Babic, Maja Smurinic, Zorana Bujas-Petkovic, Branimir Jernej.   

Abstract

Disturbances in the expression/function of the 5-HT2A receptor are implicated in autism. The association of the 5-HT2A receptor gene with autism was studied in the Croatian population. Distribution frequencies for alleles, genotypes and haplotypes of -1438 A/G and His452Tyr polymorphisms were compared in samples of 103 autistic and 214 control subjects. Significant overrepresentation of the G allele and the GG genotype of the -1438 A/G polymorphism was observed in group of autistic subjects, supporting the possible involvement of the 5-HT2A receptor in the development of autism. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20471101     DOI： 10.1016/j.psychres.2010.04.007

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  7 in total

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  7 in total

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