Ari Shechter1, France Varin, Diane B Boivin. 1. Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal Quebec, Canada.
Abstract
STUDY OBJECTIVES: Women experience insomnia more frequently than men. Menstrual cycle changes in reproductive hormones and circadian rhythms may contribute to sleep disruptions. Our aim, therefore, was to clarify the interaction between menstrual and circadian processes as it affects sleep. DESIGN: Participants entered the laboratory during the mid-follicular (MF) and mid-luteal (ML) phases of their menstrual cycle for an ultra-rapid sleep-wake cycle (URSW) procedure, consisting of 36 cycles of 60-min wake episodes alternating with 60-min nap opportunities. This procedure concluded with an ad libitum nap episode. SETTING: Time-isolation suite. PARTICIPANTS: Eight unmedicated, physically and mentally healthy females with regular ovulatory menstrual cycles. INTERVENTIONS: N/A. MEASUREMENTS: Polysomnographic sleep from nocturnal sleep episodes and 60-min naps; subjective alertness; core body temperature (CBT); salivary melatonin; urinary estradiol; and urinary progesterone. RESULTS: Increased CBT values at night and decreased CBT amplitude were observed during ML compared to MF. Circadian phase of CBT and the circadian melatonin profile were unaffected by menstrual phase. All analyzed sleep parameters showed a circadian variation throughout the URSW procedure, with no menstrual phase differences observed for most, including slow wave sleep (SWS). The circadian variation of REM sleep duration, however, was sensitive to menstrual phase, with reduced REM sleep during ML at circadian phase 0 degrees and 30 degrees. CONCLUSIONS: Moderate but significant changes in REM sleep across the menstrual and circadian cycles were observed. These results support an interaction between circadian and menstrual processes in the regulation of REM sleep.
STUDY OBJECTIVES:Women experience insomnia more frequently than men. Menstrual cycle changes in reproductive hormones and circadian rhythms may contribute to sleep disruptions. Our aim, therefore, was to clarify the interaction between menstrual and circadian processes as it affects sleep. DESIGN:Participants entered the laboratory during the mid-follicular (MF) and mid-luteal (ML) phases of their menstrual cycle for an ultra-rapid sleep-wake cycle (URSW) procedure, consisting of 36 cycles of 60-min wake episodes alternating with 60-min nap opportunities. This procedure concluded with an ad libitum nap episode. SETTING: Time-isolation suite. PARTICIPANTS: Eight unmedicated, physically and mentally healthy females with regular ovulatory menstrual cycles. INTERVENTIONS: N/A. MEASUREMENTS: Polysomnographic sleep from nocturnal sleep episodes and 60-min naps; subjective alertness; core body temperature (CBT); salivary melatonin; urinary estradiol; and urinary progesterone. RESULTS: Increased CBT values at night and decreased CBT amplitude were observed during ML compared to MF. Circadian phase of CBT and the circadian melatonin profile were unaffected by menstrual phase. All analyzed sleep parameters showed a circadian variation throughout the URSW procedure, with no menstrual phase differences observed for most, including slow wave sleep (SWS). The circadian variation of REM sleep duration, however, was sensitive to menstrual phase, with reduced REM sleep during ML at circadian phase 0 degrees and 30 degrees. CONCLUSIONS: Moderate but significant changes in REM sleep across the menstrual and circadian cycles were observed. These results support an interaction between circadian and menstrual processes in the regulation of REM sleep.
Authors: K Shibui; M Uchiyama; M Okawa; Y Kudo; K Kim; X Liu; Y Kamei; T Hayakawa; T Akamatsu; K Ohta; K Ishibashi Journal: Biol Psychiatry Date: 2000-12-01 Impact factor: 13.382
Authors: T Hori; Y Sugita; E Koga; S Shirakawa; K Inoue; S Uchida; H Kuwahara; M Kousaka; T Kobayashi; Y Tsuji; M Terashima; K Fukuda; N Fukuda Journal: Psychiatry Clin Neurosci Date: 2001-06 Impact factor: 5.188
Authors: M Ito; M Kohsaka; N Fukuda; K Honma; S Honma; Y Katsuno; H Honma; I Kawai; N Morita; T Miyamoto Journal: Jpn J Psychiatry Neurol Date: 1993-06
Authors: M M Heitkemper; K C Cain; W Deechakawan; A Poppe; S-E Jun; R L Burr; M E Jarrett Journal: Neurogastroenterol Motil Date: 2012-04-03 Impact factor: 3.598
Authors: Kara A Michels; Pauline Mendola; Karen C Schliep; Edwina H Yeung; Aijun Ye; Galit L Dunietz; Jean Wactawski-Wende; Keewan Kim; Joshua R Freeman; Enrique F Schisterman; Sunni L Mumford Journal: Chronobiol Int Date: 2019-11-28 Impact factor: 2.877
Authors: M Kathleen B Lustyk; Haley A C Douglas; Elizabeth A Shilling; Nancy F Woods Journal: Int J Psychophysiol Date: 2012-10-23 Impact factor: 2.997
Authors: Diane B Boivin; Ari Shechter; Philippe Boudreau; Esmot Ara Begum; Ng Mien Kwong Ng Ying-Kin Journal: Proc Natl Acad Sci U S A Date: 2016-09-12 Impact factor: 11.205