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Literature DB >> 2046753

Humanized antibodies for therapy.

Abstract

Protein engineering has made it possible to combine the binding sites of murine antibodies with human antibody regions. Antibodies constructed in this way have important advantages for therapy.

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Year: 1991 PMID： 2046753 DOI： 10.1038/351501a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

14 in total

Review 1. Generation of recombinant antibodies.

Authors: S M Kipriyanov; M Little
Journal: Mol Biotechnol Date: 1999-09 Impact factor: 2.695

Review 2. Generation and production of engineered antibodies.

Authors: Sergey M Kipriyanov; Fabrice Le Gall
Journal: Mol Biotechnol Date: 2004-01 Impact factor: 2.695

3. Microparticle adhesive dynamics and rolling mediated by selectin-specific antibodies under flow.

Authors: Anthony Sang Won Ham; Douglas J Goetz; Alexander L Klibanov; Michael B Lawrence
Journal: Biotechnol Bioeng Date: 2007-02-15 Impact factor: 4.530

4. In vitro immunization can elicit the expansion of diverse repertoire of B cells from peripheral blood mononuclear cells.

Authors: Shin-Ei Matsumoto; Makiko Yamashita; Yoshinori Katakura; Eri Noguchi; Yoshihiro Aiba; Akira Ichikawa; Kiichiro Teruya; Sanetaka Shirahata
Journal: Cytotechnology Date: 2006-09-05 Impact factor: 2.058

10. A human anti-Pseudomonas aeruginosa serotype O6ad immunoglobulin G1 expressed in transgenic tobacco is capable of recruiting immune system effector function in vitro.

Authors: Michael D McLean; Kurt C Almquist; Yongfing Niu; Rhonda Kimmel; Zengzu Lai; John R Schreiber; J Christopher Hall
Journal: Antimicrob Agents Chemother Date: 2007-07-02 Impact factor: 5.191

Humanized antibodies for therapy.

Review 1. Generation of recombinant antibodies.

Review 2. Generation and production of engineered antibodies.

3. Microparticle adhesive dynamics and rolling mediated by selectin-specific antibodies under flow.

4. In vitro immunization can elicit the expansion of diverse repertoire of B cells from peripheral blood mononuclear cells.

5. In vitro immunization of Epstein-Barr virus-immortalized B cells augments antigen-specific antibody production.

Review 6. The biotechnology and applications of antibody engineering.

Review 7. Applications of monoclonal antibodies in the investigation, diagnosis, and treatment of retinoblastoma.

8. The glycosylation pattern of humanized IgGI antibody (D1.3) expressed in CHO cells.

9. Prevention and reversal of experimental colitis by a monoclonal antibody which inhibits leukocyte adherence.

10. A human anti-Pseudomonas aeruginosa serotype O6ad immunoglobulin G1 expressed in transgenic tobacco is capable of recruiting immune system effector function in vitro.