Literature DB >> 20467426

The SYK tyrosine kinase: a crucial player in diverse biological functions.

Attila Mócsai1, Jürgen Ruland, Victor L J Tybulewicz.   

Abstract

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome. Studies using Drosophila melanogaster suggest that there is an evolutionarily ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of the diverse functions of SYK and how this is being translated for therapeutic purposes.

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Year:  2010        PMID： 20467426      PMCID： PMC4782221          DOI： 10.1038/nri2765

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  190 in total

1.  Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.

Authors:  K Fütterer; J Wong; R A Grucza; A C Chan; G Waksman
Journal:  J Mol Biol       Date:  1998-08-21       Impact factor: 5.469

2.  The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration.

Authors:  Jurgen Schymeinsky; Anca Sindrilaru; David Frommhold; Markus Sperandio; Ronald Gerstl; Cornelia Then; Attila Mócsai; Karin Scharffetter-Kochanek; Barbara Walzog
Journal:  Blood       Date:  2006-08-01       Impact factor: 22.113

3.  Cutting edge: constitutive B cell receptor signaling is critical for basal growth of B lymphoma.

Authors:  Murali Gururajan; C Darrell Jennings; Subbarao Bondada
Journal:  J Immunol       Date:  2006-05-15       Impact factor: 5.422

Review 4.  Autoinhibition and adapter function of Syk.

Authors:  Yogesh Kulathu; Gesina Grothe; Michael Reth
Journal:  Immunol Rev       Date:  2009-11       Impact factor: 12.988

5.  The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.

Authors:  Attila Mócsai; Mary Beth Humphrey; Jessica A G Van Ziffle; Yongmei Hu; Andrew Burghardt; Steven C Spusta; Sharmila Majumdar; Lewis L Lanier; Clifford A Lowell; Mary C Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-08       Impact factor: 11.205

6.  T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.

Authors:  L Zeitlmann; T Knorr; M Knoll; C Romeo; P Sirim; W Kolanus
Journal:  J Biol Chem       Date:  1998-06-19       Impact factor: 5.157

7.  Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas.

Authors:  A L Feldman; D X Sun; M E Law; A J Novak; A D Attygalle; E C Thorland; S R Fink; J A Vrana; B L Caron; W G Morice; E D Remstein; K L Grogg; P J Kurtin; W R Macon; A Dogan
Journal:  Leukemia       Date:  2008-04-10       Impact factor: 11.528

8.  The MAGUK family protein CARD11 is essential for lymphocyte activation.

Authors:  Hiromitsu Hara; Teiji Wada; Chris Bakal; Ivona Kozieradzki; Shinobu Suzuki; Nobutaka Suzuki; Mai Nghiem; Emily K Griffiths; Connie Krawczyk; Birgit Bauer; Fulvio D'Acquisto; Sankar Ghosh; Wen Chen Yeh; Gottfried Baier; Robert Rottapel; Josef M Penninger
Journal:  Immunity       Date:  2003-06       Impact factor: 31.745

9.  Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin.

Authors:  Karel Otero; Isaiah R Turnbull; Pietro Luigi Poliani; William Vermi; Elisa Cerutti; Taiki Aoshi; Ilaria Tassi; Toshiyuki Takai; Samuel L Stanley; Mark Miller; Andrey S Shaw; Marco Colonna
Journal:  Nat Immunol       Date:  2009-06-07       Impact factor: 25.606

10.  Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.

Authors:  Olaf Gross; Hendrik Poeck; Michael Bscheider; Catherine Dostert; Nicole Hannesschläger; Stefan Endres; Gunther Hartmann; Aubry Tardivel; Edina Schweighoffer; Victor Tybulewicz; Attila Mocsai; Jürg Tschopp; Jürgen Ruland
Journal:  Nature       Date:  2009-04-01       Impact factor: 49.962
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  451 in total

1.  Hypertensive renal injury is associated with gene variation affecting immune signaling.

Authors:  Michael C Braun; Stacy M Herring; Nisha Gokul; Monique Monita; Rebecca Bell; Yaming Zhu; Manuel L Gonzalez-Garay; Scott E Wenderfer; Peter A Doris
Journal:  Circ Cardiovasc Genet       Date:  2014-11-03

Review 2.  Innate immune signaling in defense against intestinal microbes.

Authors:  Melissa A Kinnebrew; Eric G Pamer
Journal:  Immunol Rev       Date:  2012-01       Impact factor: 12.988

3.  Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.

Authors:  Simão Luz; Patthara Kongsuphol; Ana Isabel Mendes; Francisco Romeiras; Marisa Sousa; Rainer Schreiber; Paulo Matos; Peter Jordan; Anil Mehta; Margarida D Amaral; Karl Kunzelmann; Carlos M Farinha
Journal:  Mol Cell Biol       Date:  2011-09-19       Impact factor: 4.272

Review 4.  C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses.

Authors:  Lara M Kingeter; Xin Lin
Journal:  Cell Mol Immunol       Date:  2012-01-16       Impact factor: 11.530

5.  Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response.

Authors:  Ahsan F Malik; Rafaz Hoque; Xinshou Ouyang; Ayaz Ghani; Enping Hong; Khadija Khan; Laura Beth Moore; Gilbert Ng; Fay Munro; Richard A Flavell; Yan Shi; Themis R Kyriakides; Wajahat Z Mehal
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-22       Impact factor: 11.205

6.  Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.

Authors:  Liang Xue; Wen-Horng Wang; Anton Iliuk; Lianghai Hu; Jacob A Galan; Shuai Yu; Michael Hans; Robert L Geahlen; W Andy Tao
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-26       Impact factor: 11.205

7.  Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells.

Authors:  Daniel Klimmeck; Jenny Hansson; Simon Raffel; Sergey Y Vakhrushev; Andreas Trumpp; Jeroen Krijgsveld
Journal:  Mol Cell Proteomics       Date:  2012-03-27       Impact factor: 5.911

8.  Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases.

Authors:  Peter Blomgren; Jayaraman Chandrasekhar; Julie A Di Paolo; Wanchi Fung; Guoju Geng; Carmen Ip; Randall Jones; Jeffrey E Kropf; Eric B Lansdon; Seung Lee; Jennifer R Lo; Scott A Mitchell; Bernard Murray; Chris Pohlmeyer; Aaron Schmitt; Kimberly Suekawa-Pirrone; Sarah Wise; Jin-Ming Xiong; Jianjun Xu; Helen Yu; Zhongdong Zhao; Kevin S Currie
Journal:  ACS Med Chem Lett       Date:  2020-02-12       Impact factor: 4.345

9.  SYK is a critical regulator of FLT3 in acute myeloid leukemia.

Authors:  Alexandre Puissant; Nina Fenouille; Gabriela Alexe; Yana Pikman; Christopher F Bassil; Swapnil Mehta; Jinyan Du; Julhash U Kazi; Frédéric Luciano; Lars Rönnstrand; Andrew L Kung; Jon C Aster; Ilene Galinsky; Richard M Stone; Daniel J DeAngelo; Michael T Hemann; Kimberly Stegmaier
Journal:  Cancer Cell       Date:  2014-02-10       Impact factor: 31.743

Review 10.  Targeting the Fc receptor in autoimmune disease.

Authors:  Xinrui Li; Robert P Kimberly
Journal:  Expert Opin Ther Targets       Date:  2014-03       Impact factor: 6.902
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