BACKGROUND: Monocytes and macrophages have been shown to play major roles in the progression of atherosclerosis. This study examined whether the circulating monocyte count can be used to predict coronary plaque progression of non-culprit intermediate lesions in acute myocardial infarction (AMI). METHODS AND RESULTS: Intravascular ultrasound findings of non-culprit intermediate plaque in 90 patients were analyzed in the acute phase and at a 7-month follow up. A higher peak monocyte count after AMI was associated with a greater plaque volume change (r=0.32, P=0.002). Multivariate analysis showed that a peak monocyte count of > or =800 /mm(3) was an independent predictor of plaque progression (odds ratio 5.02, P=0.005). High monocyte (> or =800 /mm(3)) at baseline had a higher monocyte count at 7-month follow up than did those with a lower count (368+/-109 vs 263+/-64 /mm(3), P<0.0001). Moreover, the monocyte count at the 7-month follow up was also associated with plaque volume change (r=0.29, P=0.006). CONCLUSIONS: The results suggest that circulating monocytes play an important role in the progression of coronary plaque in AMI and that the peak monocyte count during hospitalization might be a predictor of plaque progression.
BACKGROUND: Monocytes and macrophages have been shown to play major roles in the progression of atherosclerosis. This study examined whether the circulating monocyte count can be used to predict coronary plaque progression of non-culprit intermediate lesions in acute myocardial infarction (AMI). METHODS AND RESULTS: Intravascular ultrasound findings of non-culprit intermediate plaque in 90 patients were analyzed in the acute phase and at a 7-month follow up. A higher peak monocyte count after AMI was associated with a greater plaque volume change (r=0.32, P=0.002). Multivariate analysis showed that a peak monocyte count of > or =800 /mm(3) was an independent predictor of plaque progression (odds ratio 5.02, P=0.005). High monocyte (> or =800 /mm(3)) at baseline had a higher monocyte count at 7-month follow up than did those with a lower count (368+/-109 vs 263+/-64 /mm(3), P<0.0001). Moreover, the monocyte count at the 7-month follow up was also associated with plaque volume change (r=0.29, P=0.006). CONCLUSIONS: The results suggest that circulating monocytes play an important role in the progression of coronary plaque in AMI and that the peak monocyte count during hospitalization might be a predictor of plaque progression.
Authors: Wuzhou Wan; Jean K Lim; Michail S Lionakis; Aymeric Rivollier; David H McDermott; Brian L Kelsall; Joshua M Farber; Philip M Murphy Journal: Circ Res Date: 2011-06-16 Impact factor: 17.367
Authors: Jing Li; Andreas J Flammer; Martin K Reriani; Yoshiki Matsuo; Rajiv Gulati; Paul A Friedman; Randal J Thomas; Nicole P Sandhu; Lilach O Lerman; Amir Lerman Journal: Circ J Date: 2012-12-06 Impact factor: 2.993
Authors: Shekhar H Deo; Nathan T Jenkins; Jaume Padilla; Alan R Parrish; Paul J Fadel Journal: Am J Physiol Regul Integr Comp Physiol Date: 2013-09-25 Impact factor: 3.619
Authors: Metin Çağdaş; Süleyman Karakoyun; Mahmut Yesin; İbrahim Rencüzoğulları; Yavuz Karabağ; Mahmut Uluganyan; Mustafa Ozan Gürsoy; İnanç Artaç; Doğan İliş; Eray Atalay; Öznur Sadioğlu Çağdaş Journal: Acta Cardiol Sin Date: 2018-01 Impact factor: 2.672