Literature DB >> 20466531

Rab GEFs and GAPs.

Francis Barr1, David G Lambright.   

Abstract

Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain. Recent structural and cell biological studies shed new light on the mechanisms of Rab GEF and GAP action, and the cellular trafficking pathways they act in. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20466531      PMCID： PMC2929657          DOI： 10.1016/j.ceb.2010.04.007

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  107 in total

1.  First crystallographic models of human TBC domains in the context of a family-wide structural analysis.

Authors:  Wolfram Tempel; Yufeng Tong; Svetoslav Dimov; Alexey Bochkarev; Heewon Park
Journal:  Proteins       Date:  2008-04

2.  Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.

Authors:  Genaro Patino-Lopez; Xiaoyun Dong; Khadija Ben-Aissa; Kelsie M Bernot; Takashi Itoh; Mitsunori Fukuda; Michael J Kruhlak; Lawrence E Samelson; Stephen Shaw
Journal:  J Biol Chem       Date:  2008-04-30       Impact factor: 5.157

3.  Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein.

Authors:  Miyuki Sato; Ken Sato; Willisa Liou; Saumya Pant; Akihiro Harada; Barth D Grant
Journal:  EMBO J       Date:  2008-03-20       Impact factor: 11.598

4.  Varp interacts with Rab38 and functions as its potential effector.

Authors:  Fang Wang; Haiwei Zhang; Xinjun Zhang; Yinyin Wang; Fangli Ren; Xiaoning Zhang; Yonggong Zhai; Zhijie Chang
Journal:  Biochem Biophys Res Commun       Date:  2008-05-12       Impact factor: 3.575

5.  Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5.

Authors:  Irfan J Lodhi; Dave Bridges; Shian-Huey Chiang; Yanling Zhang; Alan Cheng; Lynn M Geletka; Lois S Weisman; Alan R Saltiel
Journal:  Mol Biol Cell       Date:  2008-04-23       Impact factor: 4.138

6.  Crag regulates epithelial architecture and polarized deposition of basement membrane proteins in Drosophila.

Authors:  Natalie Denef; Yu Chen; Stephen D Weeks; Gail Barcelo; Trudi Schüpbach
Journal:  Dev Cell       Date:  2008-03       Impact factor: 12.270

7.  Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase.

Authors:  Christopher L Brett; Rachael L Plemel; Braden T Lobingier; Braden T Lobinger; Marissa Vignali; Stanley Fields; Alexey J Merz
Journal:  J Cell Biol       Date:  2008-09-22       Impact factor: 10.539

8.  The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes.

Authors:  Yiying Cai; Harvey F Chin; Darina Lazarova; Shekar Menon; Chunmei Fu; Huaqing Cai; Anthony Sclafani; David W Rodgers; Enrique M De La Cruz; Susan Ferro-Novick; Karin M Reinisch
Journal:  Cell       Date:  2008-06-27       Impact factor: 41.582

9.  The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues.

Authors:  Andrea Scrima; Christoph Thomas; Delia Deaconescu; Alfred Wittinghofer
Journal:  EMBO J       Date:  2008-02-28       Impact factor: 11.598

10.  Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes.

Authors:  Ana C Figueiredo; Christina Wasmeier; Abul K Tarafder; José S Ramalho; Rudi A Baron; Miguel C Seabra
Journal:  J Biol Chem       Date:  2008-06-17       Impact factor: 5.157
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  186 in total

Review 1.  Retrograde vesicle transport in the Golgi.

Authors:  Nathanael P Cottam; Daniel Ungar
Journal:  Protoplasma       Date:  2011-12-12       Impact factor: 3.356

2.  Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex.

Authors:  Cornelia Bröcker; Anne Kuhlee; Christos Gatsogiannis; Henning J kleine Balderhaar; Carina Hönscher; Siegfried Engelbrecht-Vandré; Christian Ungermann; Stefan Raunser
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-25       Impact factor: 11.205

3.  Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells.

Authors:  Yi Sun; Philip J Bilan; Zhi Liu; Amira Klip
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-01       Impact factor: 11.205

Review 4.  Coordination between RAB GTPase and phosphoinositide regulation and functions.

Authors:  Steve Jean; Amy A Kiger
Journal:  Nat Rev Mol Cell Biol       Date:  2012-06-22       Impact factor: 94.444

5.  EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells.

Authors:  Akane Imai; Sumio Yoshie; Koutaro Ishibashi; Maiko Haga-Tsujimura; Tomoko Nashida; Hiromi Shimomura; Mitsunori Fukuda
Journal:  J Biol Chem       Date:  2011-08-05       Impact factor: 5.157

Review 6.  New links between vesicle coats and Rab-mediated vesicle targeting.

Authors:  Cortney G Angers; Alexey J Merz
Journal:  Semin Cell Dev Biol       Date:  2010-07-17       Impact factor: 7.727

7.  Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase.

Authors:  Dmitri Samovski; Xiong Su; Yingcheng Xu; Nada A Abumrad; Philip D Stahl
Journal:  J Lipid Res       Date:  2012-02-06       Impact factor: 5.922

8.  Silencing of TBC1D15 promotes RhoA activation and membrane blebbing.

Authors:  Yuko Takahara; Masao Maeda; Hitoki Hasegawa; Satoko Ito; Toshinori Hyodo; Eri Asano; Masahide Takahashi; Michinari Hamaguchi; Takeshi Senga
Journal:  Mol Cell Biochem       Date:  2013-12-14       Impact factor: 3.396

9.  The GTPase-deficient Rab27A(Q78L) mutant inhibits melanosome transport in melanocytes through trapping of Rab27A effector protein Slac2-a/melanophilin in their cytosol: development of a novel melanosome-targetinG tag.

Authors:  Morié Ishida; Saki P Arai; Norihiko Ohbayashi; Mitsunori Fukuda
Journal:  J Biol Chem       Date:  2014-02-28       Impact factor: 5.157

10.  Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase.

Authors:  Ganesh V Pusapati; Giovanni Luchetti; Suzanne R Pfeffer
Journal:  J Biol Chem       Date:  2012-10-22       Impact factor: 5.157
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