BACKGROUND: Intraoperative sentinel lymph node (SLN) frozen section (FS) guides immediate axillary lymph node dissection in breast cancer patients. METHODS: The Oregon Health & Science University pathology database was searched for SLN FS From October 1999 to January 1, 2009. Slides of positive cases were reviewed and metastasis sizes measured. RESULTS: Of 416 cases, 129 were positive (31%) on permanent sections and immunohistochemistry, with 79 concordant and 50 false-negative FS. Accuracy was 88%, sensitivity 61%, and specificity 100%. FS accuracy for lobular carcinoma (76%) was lower than for invasive ductal carcinoma (88%) (P = .048). FS accuracy significantly differed by size of nodal tumor. For 49 cases of tumor </= 2 mm (isolated tumor cells plus micrometastases), the accuracy of FS was 18%; for 77 cases of >2-mm metastases, accuracy was 90% (P < .0001). CONCLUSIONS: False-negative FS were predominantly small nodal tumor deposits not sampled at FS. Although accuracy was lower, SLN FS is still beneficial in lobular carcinoma, but not ductal carcinoma in situ. Copyright 2010 Elsevier Inc. All rights reserved.
BACKGROUND: Intraoperative sentinel lymph node (SLN) frozen section (FS) guides immediate axillary lymph node dissection in breast cancerpatients. METHODS: The Oregon Health & Science University pathology database was searched for SLN FS From October 1999 to January 1, 2009. Slides of positive cases were reviewed and metastasis sizes measured. RESULTS: Of 416 cases, 129 were positive (31%) on permanent sections and immunohistochemistry, with 79 concordant and 50 false-negative FS. Accuracy was 88%, sensitivity 61%, and specificity 100%. FS accuracy for lobular carcinoma (76%) was lower than for invasive ductal carcinoma (88%) (P = .048). FS accuracy significantly differed by size of nodal tumor. For 49 cases of tumor </= 2 mm (isolated tumor cells plus micrometastases), the accuracy of FS was 18%; for 77 cases of >2-mm metastases, accuracy was 90% (P < .0001). CONCLUSIONS: False-negative FS were predominantly small nodal tumor deposits not sampled at FS. Although accuracy was lower, SLN FS is still beneficial in lobular carcinoma, but not ductal carcinoma in situ. Copyright 2010 Elsevier Inc. All rights reserved.
Authors: Catherine L Akay; Constance Albarracin; Tiffany Torstenson; Roland Bassett; Elizabeth A Mittendorf; Min Yi; Henry M Kuerer; Gildy V Babiera; Isabelle Bedrosian; Kelly K Hunt; Rosa F Hwang Journal: Breast J Date: 2017-06-13 Impact factor: 2.431
Authors: Anne Grabenstetter; Tracy-Ann Moo; Sabina Hajiyeva; Peter J Schüffler; Pallavi Khattar; Maria A Friedlander; Maura A McCormack; Monica Raiss; Emily C Zabor; Andrea Barrio; Monica Morrow; Marcia Edelweiss Journal: Am J Surg Pathol Date: 2019-10 Impact factor: 6.394
Authors: Lindsey McKeen-Polizzotti; Kira M Henderson; Basak Oztan; C Cagatay Bilgin; Bülent Yener; George E Plopper Journal: BMC Med Imaging Date: 2011-05-20 Impact factor: 1.930
Authors: Lindsey McKeen Polizzotti; Basak Oztan; Chris S Bjornsson; Katherine R Shubert; Bülent Yener; George E Plopper Journal: J Biomed Biotechnol Date: 2012-05-15