BACKGROUND: Intraoperative identification of sentinel lymph node (SLN) metastases in breast cancer patients results in synchronous axillary lymph node dissection. We examined the effect of false-negative SLN biopsy on breast cancer treatments and recurrence rate. METHODS: Patient and tumor characteristics, intraoperative and final SLN biopsy results, and treatments of patients with and without recurrence were compared. RESULTS: Recurrence rates for patients with true-positive SLN biopsy (9%) were significantly higher than rates for false-negative SLN biopsy patients (2%). Recurrence rates were significantly higher for patients with primary tumors greater than 2 cm, positive lymph nodes greater than 2 mm, and tumors with negative hormone receptors, and varied with treatment extent. CONCLUSIONS: Patients with greater amounts of disease in the breast and axilla required more treatment and had a higher recurrence rate. False-negative SLN evaluation occurred more commonly in patients with less lymph node metastasis and was not associated with an increased recurrence rate. Copyright 2010 Elsevier Inc. All rights reserved.
BACKGROUND: Intraoperative identification of sentinel lymph node (SLN) metastases in breast cancerpatients results in synchronous axillary lymph node dissection. We examined the effect of false-negative SLN biopsy on breast cancer treatments and recurrence rate. METHODS:Patient and tumor characteristics, intraoperative and final SLN biopsy results, and treatments of patients with and without recurrence were compared. RESULTS: Recurrence rates for patients with true-positive SLN biopsy (9%) were significantly higher than rates for false-negative SLN biopsy patients (2%). Recurrence rates were significantly higher for patients with primary tumors greater than 2 cm, positive lymph nodes greater than 2 mm, and tumors with negative hormone receptors, and varied with treatment extent. CONCLUSIONS:Patients with greater amounts of disease in the breast and axilla required more treatment and had a higher recurrence rate. False-negative SLN evaluation occurred more commonly in patients with less lymph node metastasis and was not associated with an increased recurrence rate. Copyright 2010 Elsevier Inc. All rights reserved.
Authors: Torben Haugaard Jensen; Martin Bech; Tina Binderup; Arvid Böttiger; Christian David; Timm Weitkamp; Irene Zanette; Elena Reznikova; Jürgen Mohr; Fritz Rank; Robert Feidenhans'l; Andreas Kjær; Liselotte Højgaard; Franz Pfeiffer Journal: PLoS One Date: 2013-01-18 Impact factor: 3.240