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Literature DB >> 20465393

Mechanism of lymph node metastasis in prostate cancer.

Kaustubh Datta¹, Michael Muders, Heyu Zhang, Donald J Tindall.

Abstract

Detection of lymph node metastases indicates poor prognosis for prostate cancer patients. Therefore, elucidation of the mechanism(s) of lymph node metastasis is important to understand the progression of prostate cancer and also to develop therapeutic interventions. In this article, the known mechanisms for lymph node metastasis are discussed and the involvement of lymphatic vessels in prostate cancer lymph node metastasis is comprehensively summarized. In addition, contradictory findings regarding the importance of lymphangiogenesis in facilitating lymph node metastasis in prostate cancer are pointed out and reconcilation is attempted.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2010 PMID： 20465393 PMCID： PMC2892838 DOI： 10.2217/fon.10.33

Source DB: PubMed Journal: Future Oncol ISSN： 1479-6694 Impact factor: 3.404

100 in total

1. Lymph and blood vessel architecture in benign and malignant prostatic tissue: lack of lymphangiogenesis in prostate carcinoma assessed with novel lymphatic marker lymphatic vessel endothelial hyaluronan receptor (LYVE-1).

Authors: Lutz Trojan; Maurice Stephan Michel; Florian Rensch; David G Jackson; Peter Alken; Rainer Grobholz
Journal: J Urol Date: 2004-07 Impact factor: 7.450

2. Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors.

Authors: T A Partanen; K Alitalo; M Miettinen
Journal: Cancer Date: 1999-12-01 Impact factor: 6.860

3. Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma.

Authors: H E Wiley; E B Gonzalez; W Maki; M T Wu; S T Hwang
Journal: J Natl Cancer Inst Date: 2001-11-07 Impact factor: 13.506

4. Hepatocyte growth factor promotes lymphatic vessel formation and function.

Authors: Kentaro Kajiya; Satoshi Hirakawa; Beijia Ma; Ines Drinnenberg; Michael Detmar
Journal: EMBO J Date: 2005-07-28 Impact factor: 11.598

5. Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.

Authors: A J Leu; D A Berk; A Lymboussaki; K Alitalo; R K Jain
Journal: Cancer Res Date: 2000-08-15 Impact factor: 12.701

Review 6. The role of lymphangiogenesis in lymphatic tumour spread of urological cancers.

Authors: Christian Bolenz; Mario I Fernández; Derya Tilki; Edwin Herrmann; Julia Heinzelbecker; Süleyman Ergün; Philipp Ströbel; Oliver Reich; Maurice S Michel; Lutz Trojan
Journal: BJU Int Date: 2009-07-08 Impact factor: 5.588

7. Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells.

Authors: Mitsuhiro Matsuo; Sanae Yamada; Keiichi Koizumi; Hiroaki Sakurai; Ikuo Saiki
Journal: Eur J Cancer Date: 2007-06-13 Impact factor: 9.162

8. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

Authors: N Weidner; P R Carroll; J Flax; W Blumenfeld; J Folkman
Journal: Am J Pathol Date: 1993-08 Impact factor: 4.307

9. VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis.

Authors: Andrew V Benest; Steven J Harper; Seppo Yla Herttuala; Kari Alitalo; David O Bates
Journal: Cardiovasc Res Date: 2007-12-07 Impact factor: 10.787

10. VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development.

Authors: E Kukk; A Lymboussaki; S Taira; A Kaipainen; M Jeltsch; V Joukov; K Alitalo
Journal: Development Date: 1996-12 Impact factor: 6.868

24 in total

Review 1. Does true Gleason pattern 3 merit its cancer descriptor?

Authors: Saiful Miah; Hashim U Ahmed; Alex Freeman; Mark Emberton
Journal: Nat Rev Urol Date: 2016-08-17 Impact factor: 14.432

Review 2. Contribution of Adipose Tissue to Development of Cancer.

Authors: Alyssa J Cozzo; Ashley M Fuller; Liza Makowski
Journal: Compr Physiol Date: 2017-12-12 Impact factor: 9.090

Review 3. Prostate Cancer Epigenetic Plasticity and Enhancer Heterogeneity: Molecular Causes, Consequences and Clinical Implications.

Authors: Jeroen Kneppers; Andries M Bergman; Wilbert Zwart
Journal: Adv Exp Med Biol Date: 2022 Impact factor: 3.650

Mechanism of lymph node metastasis in prostate cancer.

1. Lymph and blood vessel architecture in benign and malignant prostatic tissue: lack of lymphangiogenesis in prostate carcinoma assessed with novel lymphatic marker lymphatic vessel endothelial hyaluronan receptor (LYVE-1).

2. Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors.

3. Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma.

4. Hepatocyte growth factor promotes lymphatic vessel formation and function.

5. Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.

Review 6. The role of lymphangiogenesis in lymphatic tumour spread of urological cancers.

7. Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells.

8. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

9. VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis.

10. VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development.

Review 1. Does true Gleason pattern 3 merit its cancer descriptor?

Review 2. Contribution of Adipose Tissue to Development of Cancer.

Review 3. Prostate Cancer Epigenetic Plasticity and Enhancer Heterogeneity: Molecular Causes, Consequences and Clinical Implications.

4. Long noncoding RNA MALAT1 as a putative biomarker of lymph node metastasis: a meta-analysis.

Review 5. [How do metastases of urological tumors develop?].

6. The tumor microenvironment in prostate cancer: elucidating molecular pathways for therapy development.

7. Significance of lymph node metastasis in cancer dissemination of head and neck cancer.

Review 8. The role of the VEGF-C/VEGFRs axis in tumor progression and therapy.

9. Non-caveolar caveolin-1 expression in prostate cancer cells promotes lymphangiogenesis.

10. Components of cell-matrix linkage as potential new markers for prostate cancer.