INTRODUCTION: Rabies is an acute disease of the central nervous system and is responsible for the deaths of thousands of humans, wild animals and livestock, particularly cattle, as well as causing major economic losses. This study describes the genetic characterization of rabies virus variants that circulate in Desmodus rotundus populations and are transmitted to herbivores. METHODS: Fifty rabies virus isolates from bovines and equines in the States of São Paulo and Minas Gerais, Brazil, were genetically characterized and compared with sequences retrieved from GenBank. RESULTS: Two clusters (I and II) with mean nucleotide identities of 99.1 and 97.6% were found. The first of these contained nearly all the samples analyzed. Lineages from other Brazilian states grouped in cluster II. CONCLUSIONS: Analysis of the amino acid sequences of the N proteins revealed the existence of genetic markers that may indicate possible variations between geographic regions, although the biologically active regions are conserved within the species over space and time.
INTRODUCTION: Rabies is an acute disease of the central nervous system and is responsible for the deaths of thousands of humans, wild animals and livestock, particularly cattle, as well as causing major economic losses. This study describes the genetic characterization of rabies virus variants that circulate in Desmodus rotundus populations and are transmitted to herbivores. METHODS: Fifty rabies virus isolates from bovines and equines in the States of São Paulo and Minas Gerais, Brazil, were genetically characterized and compared with sequences retrieved from GenBank. RESULTS: Two clusters (I and II) with mean nucleotide identities of 99.1 and 97.6% were found. The first of these contained nearly all the samples analyzed. Lineages from other Brazilian states grouped in cluster II. CONCLUSIONS: Analysis of the amino acid sequences of the N proteins revealed the existence of genetic markers that may indicate possible variations between geographic regions, although the biologically active regions are conserved within the species over space and time.
Authors: Gustavo Puglia Machado; João Marcelo Azevedo de Paula Antunes; Wilson Uieda; Alexander Welker Biondo; Tatiana Morosini de Andrade Cruvinel; Ana Paula Kataoka; Luzia Fátima Alves Martorelli; David de Jong; Jeanne Margareth Gimenes Amaral; Estevam Guilherme Lux Hoppe; Guilherme Guerra Neto; Jane Megid Journal: Primates Date: 2012-03-20 Impact factor: 2.163
Authors: Nobuyuki Mochizuki; Hiroyuki Kawasaki; Maria Lcr Silva; José Ab Afonso; Takuya Itou; Fumio H Ito; Takeo Sakai Journal: BMC Res Notes Date: 2012-01-16
Authors: S R Favoretto; C C de Mattos; C A de Mattos; A C A Campos; D R V Sacramento; E L Durigon Journal: Epidemiol Infect Date: 2013-02-22 Impact factor: 4.434