| Literature DB >> 20464129 |
Marley García Parra1, Lianet Monzote Fidalgo, Judith Mendiola Martinez, Ana Margarita Montalvo Alvarez, Olga Valdés Iglesias.
Abstract
In this study, a methanolic extract from Echinaster (Othilia) echinophorus was evaluated for activity against Leishmania amazonensis. The extract showed activity against the promastigote and amastigote forms with IC50 values of 62.9 and 37.5 microg.mL-1 respectively. This extract showed a moderate toxicity on macrophages from BALB/c mice. A dose of 100 mg/kg/day was effective when administered during 15 days by intraperitoneal route to BALB/c mice infected experimentally.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20464129 DOI： 10.1590/s0036-46652010000200005
Source DB: PubMed Journal: Rev Inst Med Trop Sao Paulo ISSN： 0036-4665 Impact factor: 1.846