OBJECTIVE: The efficacy of endoscopic screening for esophageal cancer in patients with hypopharyngeal cancer remains controversial and its impact on prognosis has not been adequately discussed. We studied the use of endoscopic screening to detect esophageal cancer in hypopharyngeal cancer patients by analyzing the incidence, stage and prognosis. METHODS: We included 64 patients with hypopharyngeal cancer who received radical radiotherapy at our institute. Chromoendoscopic esophageal examinations with Lugol dye solution were routinely performed at and after treatment for hypopharyngeal cancer. RESULTS: Twenty-eight esophageal cancers were detected in 28 (41%) patients (18 synchronous and 10 metachronous cancers). Of the 28 cancers, 23 were stage 0 or I cancer and 15 of these were treated with endoscopic resection. Local control was achieved in all of these 23 stage 0 or I cancers. The 5-year overall survival rates with esophageal cancer were 83% in stage 0, 47% in stage I and 0% in stage IIA-IVB. CONCLUSIONS: This study showed a strikingly high incidence of esophageal cancer in hypopharyngeal cancer patients. We suppose that the combination of early detection by chromoendoscopic examination and endoscopic resection for associated esophageal cancer in hypopharyngeal cancer patients improve prognosis and maintain quality of life.
OBJECTIVE: The efficacy of endoscopic screening for esophageal cancer in patients with hypopharyngeal cancer remains controversial and its impact on prognosis has not been adequately discussed. We studied the use of endoscopic screening to detect esophageal cancer in hypopharyngeal cancerpatients by analyzing the incidence, stage and prognosis. METHODS: We included 64 patients with hypopharyngeal cancer who received radical radiotherapy at our institute. Chromoendoscopic esophageal examinations with Lugol dye solution were routinely performed at and after treatment for hypopharyngeal cancer. RESULTS: Twenty-eight esophageal cancers were detected in 28 (41%) patients (18 synchronous and 10 metachronous cancers). Of the 28 cancers, 23 were stage 0 or I cancer and 15 of these were treated with endoscopic resection. Local control was achieved in all of these 23 stage 0 or I cancers. The 5-year overall survival rates with esophageal cancer were 83% in stage 0, 47% in stage I and 0% in stage IIA-IVB. CONCLUSIONS: This study showed a strikingly high incidence of esophageal cancer in hypopharyngeal cancerpatients. We suppose that the combination of early detection by chromoendoscopic examination and endoscopic resection for associated esophageal cancer in hypopharyngeal cancerpatients improve prognosis and maintain quality of life.
Authors: Oisín Bugter; Dirk L P van Iwaarden; Emilie A C Dronkers; Martine J de Herdt; Marjan H Wieringa; Gerda M Verduijn; Marc A M Mureau; Ivo Ten Hove; Esther van Meerten; José A Hardillo; Robert J Baatenburg de Jong Journal: Head Neck Date: 2019-01-16 Impact factor: 3.147
Authors: Hyun Lim; Do Hoon Kim; Hwoon Yong Jung; Eun Jeong Gong; Hee Kyong Na; Ji Yong Ahn; Mi Young Kim; Jeong Hoon Lee; Kwi Sook Choi; Kee Don Choi; Ho June Song; Gin Hyug Lee; Jin Ho Kim Journal: Gut Liver Date: 2015-03 Impact factor: 4.519
Authors: Oisín Bugter; Steffi E M van de Ven; Jose A Hardillo; Marco J Bruno; Arjun D Koch; Robert J Baatenburg de Jong Journal: Head Neck Date: 2018-12-28 Impact factor: 3.147