Literature DB >> 20462963

Kidney disease associated with plasma cell dyscrasias.

Eliot C Heher1, Nelson B Goes, Thomas R Spitzer, Noopur S Raje, Benjamin D Humphreys, Kenneth C Anderson, Paul G Richardson.   

Abstract

Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury. Other recent advances in the field include the introduction of an assay for free light chains and the use of novel antiplasma cell agents that can reverse renal failure in some cases. The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve.

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Year:  2010        PMID: 20462963      PMCID: PMC3324369          DOI: 10.1182/blood-2010-03-258608

Source DB:  PubMed          Journal:  Blood        ISSN: 0006-4971            Impact factor:   22.113


  90 in total

1.  Somatic mutations of the L12a gene in V-kappa(1) light chain deposition disease: potential effects on aberrant protein conformation and deposition.

Authors:  R Vidal; F Goñi; F Stevens; P Aucouturier; A Kumar; B Frangione; J Ghiso; G Gallo
Journal:  Am J Pathol       Date:  1999-12       Impact factor: 4.307

Review 2.  Light chains: heavy burden in kidney transplantation.

Authors:  Eliot C Heher; Thomas R Spitzer; Nelson B Goes
Journal:  Transplantation       Date:  2009-04-15       Impact factor: 4.939

3.  More studies are needed to assess the performance of serum free light chain measurement for the diagnosis of B-cell disorders in routine clinical practice.

Authors:  Pieter Vermeersch; Godelieve Mariën; Xavier Bossuyt
Journal:  Br J Haematol       Date:  2008-07-30       Impact factor: 6.998

4.  Endocytosis of light chains induces cytokines through activation of NF-kappaB in human proximal tubule cells.

Authors:  Sule Sengul; Craig Zwizinski; Eric E Simon; Aditi Kapasi; Pravin C Singhal; Vecihi Batuman
Journal:  Kidney Int       Date:  2002-12       Impact factor: 10.612

5.  Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition.

Authors:  Silke Meister; Ulrich Schubert; Kirsten Neubert; Kai Herrmann; Renate Burger; Martin Gramatzki; Sabine Hahn; Sandra Schreiber; Sabine Wilhelm; Martin Herrmann; Hans-Martin Jäck; Reinhard E Voll
Journal:  Cancer Res       Date:  2007-02-15       Impact factor: 12.701

6.  BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma.

Authors:  Ruben Niesvizky; David S Jayabalan; Paul J Christos; Jessica R Furst; Tara Naib; Scott Ely; Jessica Jalbrzikowski; Roger N Pearse; Faiza Zafar; Karen Pekle; April Larow; Richard Lent; Tomer Mark; Hearn J Cho; Tsiporah Shore; Jeffrey Tepler; John Harpel; Michael W Schuster; Susan Mathew; John P Leonard; Madhu Mazumdar; Selina Chen-Kiang; Morton Coleman
Journal:  Blood       Date:  2007-11-07       Impact factor: 22.113

7.  MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma.

Authors:  Masahisa Jinushi; Matthew Vanneman; Nikhil C Munshi; Yu-Tzu Tai; Rao H Prabhala; Jerome Ritz; Donna Neuberg; Kenneth C Anderson; Daniel Ruben Carrasco; Glenn Dranoff
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-17       Impact factor: 11.205

8.  Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group.

Authors: 
Journal:  Br J Haematol       Date:  2003-06       Impact factor: 6.998

9.  Role of the monoclonal kappa chain V domain and reversibility of renal damage in a transgenic model of acquired Fanconi syndrome.

Authors:  Christophe Sirac; Frank Bridoux; Claire Carrion; Olivier Devuyst; Béatrice Fernandez; Jean-Michel Goujon; Chahrazed El Hamel; Jean-Claude Aldigier; Guy Touchard; Michel Cogné
Journal:  Blood       Date:  2006-03-16       Impact factor: 22.113

10.  Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains.

Authors:  Jerry A Katzmann; Raynell J Clark; Roshini S Abraham; Sandra Bryant; James F Lymp; Arthur R Bradwell; Robert A Kyle
Journal:  Clin Chem       Date:  2002-09       Impact factor: 8.327

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  9 in total

Review 1.  Myeloma light chain cast nephropathy, a review.

Authors:  Insara Jaffer Sathick; Maria Eleni Drosou; Nelson Leung
Journal:  J Nephrol       Date:  2018-05-05       Impact factor: 3.902

Review 2.  Monoclonal gammopathy of renal significance (MGRS): the characteristics and significance of a new meta-entity.

Authors:  Mariana Ciocchini; Jorge Arbelbide; Carlos G Musso
Journal:  Int Urol Nephrol       Date:  2017-04-19       Impact factor: 2.370

3.  Freedom isn't always free: immunoglobulin free light chains promote renal fibrosis.

Authors:  Erin B Taylor; Michael J Ryan
Journal:  J Clin Invest       Date:  2019-06-17       Impact factor: 14.808

Review 4.  Light Chain Cast Nephropathy in Multiple Myeloma: Prevalence, Impact and Management Challenges.

Authors:  Paolo Menè; Antonella Stoppacciaro; Silvia Lai; Francescaromana Festuccia
Journal:  Int J Nephrol Renovasc Dis       Date:  2022-05-13

5.  Tumor Cell-Derived Microvesicles Induced Not Epithelial-Mesenchymal Transition but Apoptosis in Human Proximal Tubular (HK-2) Cells: Implications for Renal Impairment in Multiple Myeloma.

Authors:  Aiqi Zhao; Fancong Kong; Chun-Jie Liu; Guoxin Yan; Fei Gao; Hao Guo; An-Yuan Guo; Zhichao Chen; Qiubai Li
Journal:  Int J Mol Sci       Date:  2017-02-27       Impact factor: 5.923

6.  Progression of Monoclonal Gammopathy with Undetermined Significance to Multiple Myeloma Diagnosed by Kidney Biopsy: A Case Report.

Authors:  Jin Hae Kim; Ji Won Kim; Young Nam Kim; Hye In Kim; Jun Young Kim; Ghee Young Kwon; Kihyun Kim; Hye Ryoun Jang
Journal:  Case Rep Nephrol Dial       Date:  2015-09-02

7.  Percentage of urinary albumin excretion and serum-free light-chain reduction are important determinants of renal response in myeloma patients with moderate to severe renal impairment.

Authors:  H Sugihara; D Chihara; K Seike; K Fukumoto; M Fujisawaa; Y Suehara; Y Nishida; M Takeuchi; K Matsue
Journal:  Blood Cancer J       Date:  2014-08-01       Impact factor: 11.037

8.  Bone marrow stromal cells show distinct gene expression patterns depending on symptomatically involved organs in multiple myeloma.

Authors:  S Y Kim; K Im; S N Park; B Oh; J-A Kim; S M Hwang; M Kim; S-S Yoon; D S Lee
Journal:  Blood Cancer J       Date:  2016-09-23       Impact factor: 11.037

9.  Multiple Myeloma as the Underlying Cause of Thrombotic Microangiopathy Leading to Acute Kidney Injury: Revisiting a Very Rare Entity.

Authors:  Savneek Chugh; Asim Kichloo; Firas Jafri; Liga Yusvirazi; Robert Lerner
Journal:  J Investig Med High Impact Case Rep       Date:  2017-09-22
  9 in total

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