PURPOSE: Solid ovarian tumours are uncommon in childhood. Our aim is to evaluate the outcomes in a single institution over 35 years. METHODS: We reviewed their clinical presentation, management, pathology and outcomes from 1972 to 2007. RESULTS: Fifty-three patients, with a median age of 9.2 years (range 0.9-14.2), were registered. Common symptoms at presentation were abdominal pain (75.8%) and abdominal mass (57.4%). Histopathological diagnoses were: 26 mature teratoma, 10 immature teratoma, 8 dysgerminoma, 5 granulosa cell tumours, 2 yolk sac tumours, 1 gonadoblastoma and 1 embryonal carcinoma. Staging (FIGO) for malignant/borderline tumours was: 17 stage I, 1 stage II, 8 stage III and 1 stage IV. Unilateral salpingo-oophorectomy was performed in 47 cases. Sixteen patients underwent chemotherapy after surgery (15 with platinum-based regimen) and postoperative radiotherapy was given in 5 cases. Recurrence was observed in 2 patients and one died (stage III immature teratoma) after a second relapse despite multiple chemotherapy, surgery and radiotherapy. Five-year OS and 5-year EFS were 97% and 94% respectively. CONCLUSIONS: Although rare, ovarian tumours must be included in the differential diagnosis of abdominal pain in childhood. Our results confirm their excellent prognosis using conservative surgery and platinum-based chemotherapy. The key point is to maintain excellent outcome while reducing associated morbidity and preserving fertility.
PURPOSE: Solid ovarian tumours are uncommon in childhood. Our aim is to evaluate the outcomes in a single institution over 35 years. METHODS: We reviewed their clinical presentation, management, pathology and outcomes from 1972 to 2007. RESULTS: Fifty-three patients, with a median age of 9.2 years (range 0.9-14.2), were registered. Common symptoms at presentation were abdominal pain (75.8%) and abdominal mass (57.4%). Histopathological diagnoses were: 26 mature teratoma, 10 immature teratoma, 8 dysgerminoma, 5 granulosa cell tumours, 2 yolk sac tumours, 1 gonadoblastoma and 1 embryonal carcinoma. Staging (FIGO) for malignant/borderline tumours was: 17 stage I, 1 stage II, 8 stage III and 1 stage IV. Unilateral salpingo-oophorectomy was performed in 47 cases. Sixteen patients underwent chemotherapy after surgery (15 with platinum-based regimen) and postoperative radiotherapy was given in 5 cases. Recurrence was observed in 2 patients and one died (stage III immature teratoma) after a second relapse despite multiple chemotherapy, surgery and radiotherapy. Five-year OS and 5-year EFS were 97% and 94% respectively. CONCLUSIONS: Although rare, ovarian tumours must be included in the differential diagnosis of abdominal pain in childhood. Our results confirm their excellent prognosis using conservative surgery and platinum-based chemotherapy. The key point is to maintain excellent outcome while reducing associated morbidity and preserving fertility.
Authors: D L Cass; E Hawkins; M L Brandt; M Chintagumpala; R S Bloss; A L Milewicz; P K Minifee; D E Wesson; J G Nuchtern Journal: J Pediatr Surg Date: 2001-05 Impact factor: 2.545
Authors: Antoine De Backer; Gerard C Madern; J Wolter Oosterhuis; Friederike G A J Hakvoort-Cammel; Frans W J Hazebroek Journal: Pediatr Blood Cancer Date: 2006-04 Impact factor: 3.167
Authors: J R Mann; F Raafat; K Robinson; J Imeson; P Gornall; M Phillips; M Sokal; E Gray; P McKeever; A Oakhill Journal: Med Pediatr Oncol Date: 1998-04
Authors: N M Marina; B Cushing; R Giller; L Cohen; S J Lauer; A Ablin; R Weetman; J Cullen; P Rogers; C Vinocur; C Stolar; F Rescorla; E Hawkins; S Heifetz; P V Rao; M Krailo; R P Castleberry Journal: J Clin Oncol Date: 1999-07 Impact factor: 44.544
Authors: D Billmire; C Vinocur; F Rescorla; B Cushing; W London; M Schlatter; M Davis; R Giller; S Lauer; T Olson Journal: J Pediatr Surg Date: 2004-03 Impact factor: 2.545