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Literature DB >> 20462343

From molecular mechanisms of cardiac development to genetic substrate of congenital heart diseases.

Antonella Cecchetto¹, Alessandra Rampazzo, Annalisa Angelini, Lucia Dal Bianco, Massimo Padalino, Giovanni Stellin, Luciano Daliento.

Abstract

Congenital heart disease is one of the most important chapters in medicine because its incidence is increasing and nowadays it is close to 1.2%. Most congenital heart disorders are the result of defects during embryogenesis, which implies that they are due to alterations in genes involved in cardiac development. This review summarizes current knowledge regarding the molecular mechanisms involved in cardiac development in order to clarify the genetic basis of congenital heart disease.

Entities: Disease

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Year: 2010 PMID： 20462343 DOI： 10.2217/fca.10.10

Source DB: PubMed Journal: Future Cardiol ISSN： 1479-6678

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Cited

10 in total

1. GATA5 loss-of-function mutation responsible for the congenital ventriculoseptal defect.

Authors: Dong Wei; Han Bao; Ning Zhou; Gui-Fen Zheng; Xing-Yuan Liu; Yi-Qing Yang
Journal: Pediatr Cardiol Date: 2012-09-09 Impact factor: 1.655

2. Prevalence and spectrum of PITX2c mutations associated with congenital heart disease.

Authors: Juan Wang; Yuan-Feng Xin; Wen-Jun Xu; Zhong-Min Liu; Xing-Biao Qiu; Xin-Kai Qu; Lei Xu; Xin Li; Yi-Qing Yang
Journal: DNA Cell Biol Date: 2013-10-01 Impact factor: 3.311

3. Identification of dysfunctional modules and disease genes in congenital heart disease by a network-based approach.

Authors: Danning He; Zhi-Ping Liu; Luonan Chen
Journal: BMC Genomics Date: 2011-12-02 Impact factor: 3.969

4. Stage-specific regulation of signalling pathways to differentiate pluripotent stem cells to cardiomyocytes with ventricular lineage.

Authors: Ramakanth Satthenapalli; Scott Lee; Jayanthi Bellae Papannarao; Timothy A Hore; Akash Chakraborty; Peter P Jones; Regis R Lamberts; Rajesh Katare
Journal: Stem Cell Res Ther Date: 2022-05-06 Impact factor: 6.832

10. Islet-1 may function as an assistant factor for histone acetylation and regulation of cardiac development-related transcription factor Mef2c expression.

Authors: Zhongsu Yu; Juanjuan Kong; Bo Pan; Huichao Sun; Tiewei Lv; Jing Zhu; Guoying Huang; Jie Tian
Journal: PLoS One Date: 2013-10-17 Impact factor: 3.240

10 in total

From molecular mechanisms of cardiac development to genetic substrate of congenital heart diseases.

1. GATA5 loss-of-function mutation responsible for the congenital ventriculoseptal defect.

2. Prevalence and spectrum of PITX2c mutations associated with congenital heart disease.

3. Identification of dysfunctional modules and disease genes in congenital heart disease by a network-based approach.

4. Stage-specific regulation of signalling pathways to differentiate pluripotent stem cells to cardiomyocytes with ventricular lineage.

5. Functional study of DAND5 variant in patients with Congenital Heart Disease and laterality defects.

Review 6. Associations of GATA4 genetic mutations with the risk of congenital heart disease: A meta-analysis.

Review 7. Insights into role of microRNAs in cardiac development, cardiac diseases, and developing novel therapies.

8. GATA5 loss-of-function mutations underlie tetralogy of fallot.

9. PITX2c loss-of-function mutations responsible for congenital atrial septal defects.

10. Islet-1 may function as an assistant factor for histone acetylation and regulation of cardiac development-related transcription factor Mef2c expression.