Literature DB >> 20462259

Highly alpha-selective synthesis of sialyl spirohydantoins by regiospecific domino condensation/O-->N acyl migration/N-sialylation of carbodiimides with peracetylated sialic acid.

Dengyou Zhang1, Deju Ye, Enguang Feng, Jinfang Wang, Jianmei Shi, Hualiang Jiang, Hong Liu.   

Abstract

A novel and efficient process for the synthesis of alpha-sialyl spirohydantoin analogues via one-pot sequential reaction involving various carbodiimides and peracetylated Neu5Ac is reported. BF(3) x Et(2)O mediating intramolecular N-sialylation with excellent alpha-selectivity is first demonstrated.

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Year:  2010        PMID： 20462259     DOI： 10.1021/jo100016k

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  The catalytic influence of phosphotungstic acid-functionalized Fe3O4 MNPs blended with TiO2 on the synthesis of novel spiro-acridines and the evaluation of their medicinal potential through molecular docking studies.

Authors:  Shweta Potdar; Nikita Pal; Pratibha Sharma; Ashok Kumar
Journal:  RSC Adv       Date:  2020-12-16       Impact factor: 4.036

2.  A facile synthesis of functionalized dispirooxindole derivatives via a three-component 1,3-dipolar cycloaddition reaction.

Authors:  Jun He; Guang Ouyang; Zhixiang Yuan; Rongsheng Tong; Jianyou Shi; Liang Ouyang
Journal:  Molecules       Date:  2013-05-03       Impact factor: 4.411
  2 in total

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