Literature DB >> 20461849

Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases.

Francesca Cardona1, Andrea Goti, Camilla Parmeggiani, Paolo Parenti, Matilde Forcella, Paola Fusi, Laura Cipolla, Shirley M Roberts, Gideon J Davies, Tracey M Gloster.   

Abstract

Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.

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Year:  2010        PMID： 20461849     DOI： 10.1039/b926600c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Gene Cloning, Prokaryotic Expression, and Biochemical Characterization of a Soluble Trehalase in Helicoverpa armigera Hübner (Lepidoptera: Noctuidae).

Authors:  Dong Ai; Shenhang Cheng; Hetan Chang; Ting Yang; Guirong Wang; Caihong Yu
Journal:  J Insect Sci       Date:  2018-05-01       Impact factor: 1.857

2.  Probing the Influence of Linker Length and Flexibility in the Design and Synthesis of New Trehalase Inhibitors.

Authors:  Giampiero D'Adamio; Matilde Forcella; Paola Fusi; Paolo Parenti; Camilla Matassini; Xhenti Ferhati; Costanza Vanni; Francesca Cardona
Journal:  Molecules       Date:  2018-02-16       Impact factor: 4.411

3.  Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions.

Authors:  John Ginn; Xiuju Jiang; Shan Sun; Mayako Michino; David J Huggins; Zodwa Mbambo; Robert Jansen; Kyu Y Rhee; Nancy Arango; Christopher D Lima; Nigel Liverton; Toshihiro Imaeda; Rei Okamoto; Takanobu Kuroita; Kazuyoshi Aso; Andrew Stamford; Michael Foley; Peter T Meinke; Carl Nathan; Ruslana Bryk
Journal:  ACS Infect Dis       Date:  2021-02-02       Impact factor: 5.084

4.  A trehalase from Zunongwangia sp.: characterization and improving catalytic efficiency by directed evolution.

Authors:  Qipeng Cheng; Haofeng Gao; Nan Hu
Journal:  BMC Biotechnol       Date:  2016-01-29       Impact factor: 2.563
  4 in total

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