Adam P Levene1, Robert D Goldin. 1. Department of Histopathology, Imperial College Faculty of Medicine at St Mary's Hospital, London, UK.
Abstract
AIMS: Nuclear vacuolation/glycogenation is a characteristic histological feature of non-alcoholic fatty liver disease (NAFLD) that can help distinguish it from alcohol-induced liver disease. There are, however, other associations of nuclear vacuolation of which the commonest is as a normal feature of childhood. The aim of this study was to identify how long this physiological nuclear vacuolation persists. METHODS AND RESULTS: Liver biopsy specimens from 872 patients with chronic hepatitis B virus infection (a condition known not to be associated with nuclear vacuolation) were studied to assess the frequency of nuclear vacuolation at different ages. All the patients studied had a body mass index of <25 kg/m(2) and an alcohol intake of <15 units/week, as well as no other risk factors for liver disease. It was found that the frequency of nuclear vacuolation, in the absence of NAFLD, fell from 13% at age 20-24 years to 4% in the early 30s and to 0% at age 60-64 years. CONCLUSIONS: Physiological hepatic nuclear vacuolation is common in the 20s and persists into the 30s. This knowledge can help in the assessment of liver biopsy specimens in which nuclear vacuolation is a feature.
AIMS: Nuclear vacuolation/glycogenation is a characteristic histological feature of non-alcoholic fatty liver disease (NAFLD) that can help distinguish it from alcohol-induced liver disease. There are, however, other associations of nuclear vacuolation of which the commonest is as a normal feature of childhood. The aim of this study was to identify how long this physiological nuclear vacuolation persists. METHODS AND RESULTS: Liver biopsy specimens from 872 patients with chronic hepatitis B virus infection (a condition known not to be associated with nuclear vacuolation) were studied to assess the frequency of nuclear vacuolation at different ages. All the patients studied had a body mass index of <25 kg/m(2) and an alcohol intake of <15 units/week, as well as no other risk factors for liver disease. It was found that the frequency of nuclear vacuolation, in the absence of NAFLD, fell from 13% at age 20-24 years to 4% in the early 30s and to 0% at age 60-64 years. CONCLUSIONS: Physiological hepatic nuclear vacuolation is common in the 20s and persists into the 30s. This knowledge can help in the assessment of liver biopsy specimens in which nuclear vacuolation is a feature.
Authors: Suzan Schwertheim; Daniela Westerwick; Holger Jastrow; Sarah Theurer; Christoph M Schaefer; Julia Kälsch; Dorothe Möllmann; Martin Schlattjan; Heiner Wedemeyer; Kurt Werner Schmid; Hideo A Baba Journal: J Pathol Clin Res Date: 2019-04-08
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