Literature DB >> 20459216

Optical microangiography provides depth-resolved images of directional ocular blood perfusion in posterior eye segment.

Ruikang K Wang1, Lin An, Spencer Saunders, David J Wilson.   

Abstract

In this paper, we demonstrate that the optical microangiography (OAMG) is capable of depth-resolved imaging of directional blood perfusion within both retinal and choroid in the posterior segment of human eye. The study uses an OMAG system operating at 840 nm with an imaging speed at 27,000 A-scans per second. Sequentially registered multiple OMAG projection maps of small areas ( approximately 1 mm x 1 mm) are combined to provide directional blood flow images for a larger field of view. It takes approximately 3.7 sec to image a small area (1 x 1 mm(2)), and approximately 2.5 min for a larger field (3 x 3 mm(2)). Finally, we show superior performance of OMAG in providing functional images of capillary level microcirculation at different depths of retina and choroid that correlate well with the standard retinal pathology.

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Year:  2010        PMID: 20459216      PMCID: PMC2852433          DOI: 10.1117/1.3353958

Source DB:  PubMed          Journal:  J Biomed Opt        ISSN: 1083-3668            Impact factor:   3.170


  8 in total

1.  Fourier domain optical coherence tomography achieves full range complex imaging in vivo by introducing a carrier frequency during scanning.

Authors:  Ruikang K Wang
Journal:  Phys Med Biol       Date:  2007-09-14       Impact factor: 3.609

2.  In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography.

Authors:  Lin An; Ruikang K Wang
Journal:  Opt Express       Date:  2008-07-21       Impact factor: 3.894

3.  Mapping of cerebro-vascular blood perfusion in mice with skin and skull intact by Optical Micro-AngioGraphy at 1.3 mum wavelength.

Authors:  Ruikang K Wang; Sawan Hurst
Journal:  Opt Express       Date:  2007-09-03       Impact factor: 3.894

4.  Three dimensional optical angiography.

Authors:  Ruikang K Wang; Steven L Jacques; Zhenhe Ma; Sawan Hurst; Stephen R Hanson; Andras Gruber
Journal:  Opt Express       Date:  2007-04-02       Impact factor: 3.894

5.  A hemodynamic model of the pathogenesis of age-related macular degeneration.

Authors:  E Friedman
Journal:  Am J Ophthalmol       Date:  1997-11       Impact factor: 5.258

6.  Retinal blood flow in diabetic retinopathy.

Authors:  V Patel; S Rassam; R Newsom; J Wiek; E Kohner
Journal:  BMJ       Date:  1992-09-19

7.  Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivo.

Authors:  Ruikang K Wang; Lin An
Journal:  Opt Express       Date:  2009-05-25       Impact factor: 3.894

Review 8.  The impact of ocular blood flow in glaucoma.

Authors:  Josef Flammer; Selim Orgül; Vital P Costa; Nicola Orzalesi; Günter K Krieglstein; Luis Metzner Serra; Jean-Paul Renard; Einar Stefánsson
Journal:  Prog Retin Eye Res       Date:  2002-07       Impact factor: 21.198

  8 in total
  22 in total

1.  Efficient method to suppress artifacts caused by tissue hyper-reflections in optical microangiography of retina in vivo.

Authors:  Yanping Huang; Qinqin Zhang; Ruikang K Wang
Journal:  Biomed Opt Express       Date:  2015-03-10       Impact factor: 3.732

2.  Multifunctional imaging of human retina and choroid with 1050-nm spectral domain optical coherence tomography at 92-kHz line scan rate.

Authors:  Ruikang K Wang; Lin An
Journal:  J Biomed Opt       Date:  2011-05       Impact factor: 3.170

3.  Wide field and highly sensitive angiography based on optical coherence tomography with akinetic swept source.

Authors:  Jingjiang Xu; Shaozhen Song; Wei Wei; Ruikang K Wang
Journal:  Biomed Opt Express       Date:  2016-12-22       Impact factor: 3.732

Review 4.  Optical coherence tomography based angiography [Invited].

Authors:  Chieh-Li Chen; Ruikang K Wang
Journal:  Biomed Opt Express       Date:  2017-01-24       Impact factor: 3.732

5.  Improved microcirculation imaging of human skin in vivo using optical microangiography with a correlation mapping mask.

Authors:  Woo June Choi; Roberto Reif; Siavash Yousefi; Ruikang K Wang
Journal:  J Biomed Opt       Date:  2014-03       Impact factor: 3.170

6.  Repeatability and reproducibility of optic nerve head perfusion measurements using optical coherence tomography angiography.

Authors:  Chieh-Li Chen; Karine D Bojikian; Chen Xin; Joanne C Wen; Divakar Gupta; Qinqin Zhang; Raghu C Mudumbai; Murray A Johnstone; Philip P Chen; Ruikang K Wang
Journal:  J Biomed Opt       Date:  2016-06-01       Impact factor: 3.170

7.  Advances in Doppler OCT.

Authors:  Gangjun Liu; Zhongping Chen
Journal:  Chin Opt Lett       Date:  2013       Impact factor: 2.448

8.  The Definition, Rationale, and Effects of Thresholding in OCT Angiography.

Authors:  Emily D Cole; Eric M Moult; Sabin Dang; WooJhon Choi; Stefan B Ploner; ByungKun Lee; Ricardo Louzada; Eduardo Novais; Julia Schottenhamml; Lennart Husvogt; Andreas Maier; James G Fujimoto; Nadia K Waheed; Jay S Duker
Journal:  Ophthalmol Retina       Date:  2017-04-05

9.  Structural and Functional Associations of Macular Microcirculation in the Ganglion Cell-Inner Plexiform Layer in Glaucoma Using Optical Coherence Tomography Angiography.

Authors:  Grace M Richter; Ingy Madi; Zhongdi Chu; Bruce Burkemper; Ryuna Chang; Arman Zaman; Beau Sylvester; Alena Reznik; Amir Kashani; Ruikang K Wang; Rohit Varma
Journal:  J Glaucoma       Date:  2018-03       Impact factor: 2.503

10.  Retina phantom for the evaluation of optical coherence tomography angiography based on microfluidic channels.

Authors:  Hyun-Ji Lee; Nafra M Samiudin; Tae Geol Lee; Il Doh; Sang-Won Lee
Journal:  Biomed Opt Express       Date:  2019-10-03       Impact factor: 3.732

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