OBJECTIVE: To investigate the protective effect of Marine Collagen Peptides (MCPs) on liver and renal injury in diabetic rat induced by alloxan. METHODS: Twenty-four diabetic rats were randomly divided into four groups and MCPs (0, 0.3575 g/kg bw, 1.0833 g/kg bw and 3.25 g/kg bw respectively) were given intragastrically. Liver function (ALT) and renal function (BUN) were measured before and 20 days after intervention with Marine Collagen Peptides. The SOD activity and MDA content of liver were measured 20 days after the intervention. RESULTS: There were no significant changes of ALT before and after intervention. Treatment of diabetic rats with 1.0833 g/kg bw and 3.25 g/kg bw MCPs resulted in a significant reduction in BUN. The activity of SOD was enhanced and the MDA content was decreased concomitantly in the liver of diabetic rats treated with high MCPs (3.25 g/kg bw). CONCLUSION: Marine Collagen Peptides might play a protective role on liver and renal function of alloxan-induced diabetic rats by improving antioxidant activity of the body.
OBJECTIVE: To investigate the protective effect of Marine Collagen Peptides (MCPs) on liver and renal injury in diabeticrat induced by alloxan. METHODS: Twenty-four diabeticrats were randomly divided into four groups and MCPs (0, 0.3575 g/kg bw, 1.0833 g/kg bw and 3.25 g/kg bw respectively) were given intragastrically. Liver function (ALT) and renal function (BUN) were measured before and 20 days after intervention with Marine Collagen Peptides. The SOD activity and MDA content of liver were measured 20 days after the intervention. RESULTS: There were no significant changes of ALT before and after intervention. Treatment of diabeticrats with 1.0833 g/kg bw and 3.25 g/kg bw MCPs resulted in a significant reduction in BUN. The activity of SOD was enhanced and the MDA content was decreased concomitantly in the liver of diabeticrats treated with high MCPs (3.25 g/kg bw). CONCLUSION: Marine Collagen Peptides might play a protective role on liver and renal function of alloxan-induced diabeticrats by improving antioxidant activity of the body.