Literature DB >> 20458671

Cytotoxic steroids from Polyporus umbellatus.

Ying-Yong Zhao1, Xu Chao, Yongmin Zhang, Rui-Chao Lin, Wen-Ji Sun.   

Abstract

The steroids ergone (1), (22E, 24R)-ergosta-7,22-dien-3β-ol (2), 5α,8α-epidioxy-(22E,24R) -ergosta-6,22-dien-3β-ol (3), ergosta-6,22-dien-3β,5α,6β-triol (4), and polyporusterone B (5) were isolated from Polyporus umbellatus by bioassay-guided approach. They showed potent anticancer activity against HepG2 cells. Ergone displayed remarkable anticancer activity against HepG2, Hep-2, and Hela cancer cells, of which HepG2 cells were the most sensitive. Furthermore, the cytotoxic effects of ergone on normal human cells (HUVEC) were smaller than on cancer cells. The results showed that ergone had more selective cytotoxic activity against cancer cells than against normal cells. © Georg Thieme Verlag KG Stuttgart · New York.

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Year:  2010        PMID： 20458671     DOI： 10.1055/s-0030-1249926

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  8 in total

1.  Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species.

Authors:  Tae Hwan Kim; Ju sung Kim; Zoo haye Kim; Ren Bin Huang; Ren Sheng Wang
Journal:  PLoS One       Date:  2012-10-08       Impact factor: 3.240

2.  Sclerotial formation of Polyporus umbellatus by low temperature treatment under artificial conditions.

Authors:  Yong-Mei Xing; Li-Chun Zhang; Han-Qiao Liang; Jing Lv; Chao Song; Shun-Xing Guo; Chun-Lan Wang; Tae-Soo Lee; Min-Woong Lee
Journal:  PLoS One       Date:  2013-02-20       Impact factor: 3.240

3.  Development of Microsatellite Markers Derived from Expressed Sequence Tags of Polyporales for Genetic Diversity Analysis of Endangered Polyporus umbellatus.

Authors:  Yuejin Zhang; Yuanyuan Chen; Ruihong Wang; Ailin Zeng; Michael K Deyholos; Jia Shu; Hongbo Guo
Journal:  Biomed Res Int       Date:  2015-06-03       Impact factor: 3.411

4.  A pharmaco-metabonomic study on chronic kidney disease and therapeutic effect of ergone by UPLC-QTOF/HDMS.

Authors:  Ying-Yong Zhao; Hua Chen; Ting Tian; Dan-Qian Chen; Xu Bai; Feng Wei
Journal:  PLoS One       Date:  2014-12-23       Impact factor: 3.240

5.  Armillaria mellea Symbiosis Drives Metabolomic and Transcriptomic Changes in Polyporus umbellatus Sclerotia.

Authors:  Yong-Mei Xing; Bing Li; Liu Liu; Yang Li; Shu-Xue Yin; Shu-Chao Yin; Juan Chen; Shun-Xing Guo
Journal:  Front Microbiol       Date:  2022-02-03       Impact factor: 5.640

Review 6.  Structure and Biological Activity of Ergostane-Type Steroids from Fungi.

Authors:  Vladimir N Zhabinskii; Pavel Drasar; Vladimir A Khripach
Journal:  Molecules       Date:  2022-03-24       Impact factor: 4.411

7.  ESTs analysis of putative genes engaged in Polyporus umbellatus sclerotial development.

Authors:  Chao Song; Mengmeng Liu; Yongmei Xing; Shunxing Guo
Journal:  Int J Mol Sci       Date:  2014-09-10       Impact factor: 5.923

8.  Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.

Authors:  Tae Hwan Kim; Ju Sung Kim; Zoo Haye Kim; Ren Bin Huang; Young Lye Chae; Ren Sheng Wang
Journal:  BMC Complement Altern Med       Date:  2014-07-10       Impact factor: 3.659
  8 in total

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