Literature DB >> 2045796

The M2 protein of influenza A virus is acylated.

M Veit1, H D Klenk, A Kendal, R Rott.   

Abstract

The M2 protein of influenza A virus, a 97 amino acid integral membrane protein expressed on the surface of infected cells, is covalently modified with long chain fatty acids. The fatty acid bond is sensitive to treatment with neutral hydroxylamine and mercaptoethanol, which indicates a labile thioester type linkage. Thin-layer chromatographic fatty acid analysis of [3H]myristic and [3H]palmitic acid-labelled M2 protein shows that palmitic acid is the predominant fatty acid linked to this polypeptide. Palmitoylation of M2 occurs post-translationally and causes an upward shift in the SDS-PAGE mobility of the protein.

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Year:  1991        PMID： 2045796     DOI： 10.1099/0022-1317-72-6-1461

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  28 in total

1.  Effect of cytoplasmic tail truncations on the activity of the M(2) ion channel of influenza A virus.

Authors:  K Tobler; M L Kelly; L H Pinto; R A Lamb
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

2.  Expression of the influenza A virus M2 protein is restricted to apical surfaces of polarized epithelial cells.

Authors:  P G Hughey; R W Compans; S L Zebedee; R A Lamb
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

Review 3.  Ion channels as antivirus targets.

Authors:  Xin Liang; Zhi-Yuan Li
Journal:  Virol Sin       Date:  2010-07-28       Impact factor: 4.327

4.  Intrinsic cytoskeleton-dependent clustering of influenza virus M2 protein with hemagglutinin assessed by FLIM-FRET.

Authors:  Bastian Thaa; Andreas Herrmann; Michael Veit
Journal:  J Virol       Date:  2010-09-29       Impact factor: 5.103

5.  Distinct domains of the influenza a virus M2 protein cytoplasmic tail mediate binding to the M1 protein and facilitate infectious virus production.

Authors:  Matthew F McCown; Andrew Pekosz
Journal:  J Virol       Date:  2006-08       Impact factor: 5.103

6.  Characterization of a second protein (CM2) encoded by RNA segment 6 of influenza C virus.

Authors:  S Hongo; K Sugawara; Y Muraki; F Kitame; K Nakamura
Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

Review 7.  Protein-lipid interactions critical to replication of the influenza A virus.

Authors:  Petr Chlanda; Joshua Zimmerberg
Journal:  FEBS Lett       Date:  2016-03-30       Impact factor: 4.124

8.  Influenza virus assembly and lipid raft microdomains: a role for the cytoplasmic tails of the spike glycoproteins.

Authors:  J Zhang; A Pekosz; R A Lamb
Journal:  J Virol       Date:  2000-05       Impact factor: 5.103

9.  Amphipathic Helices of Cellular Proteins Can Replace the Helix in M2 of Influenza A Virus with Only Small Effects on Virus Replication.

Authors:  Bodan Hu; Stefanie Siche; Lars Möller; Michael Veit
Journal:  J Virol       Date:  2020-01-17       Impact factor: 5.103

10.  Palmitoylation of the Rous sarcoma virus transmembrane glycoprotein is required for protein stability and virus infectivity.

Authors:  C Ochsenbauer-Jambor; D C Miller; C R Roberts; S S Rhee; E Hunter
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103
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