| Literature DB >> 20457518 |
Brian S Brown1, Ryan Keddy, Richard J Perner, Stanley DiDomenico, John R Koenig, Tammie K Jinkerson, Steven M Hannick, Heath A McDonald, Bruce R Bianchi, Prisca Honore, Pamela S Puttfarcken, Robert B Moreland, Kennan C Marsh, Connie R Faltynek, Chih-Hung Lee.
Abstract
The synthesis and SAR of a series of indazole TRPV1 antagonists leading to the discovery of 21 (ABT-116) is described. Biological studies demonstrated potent in vitro and in vivo activity for 21, as well as suitable physicochemical and pharmacokinetic properties for advancement to clinical development for pain management. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20457518 DOI： 10.1016/j.bmcl.2010.04.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823