Literature DB >> 20457476

Synthesis of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carbolines as antileishmanial agents.

Ravi Kumar1, Shahnawaz Khan, Aditya Verma, Saumya Srivastava, Preeti Viswakarma, Suman Gupta, Sanjeev Meena, Neetu Singh, Jayanta Sarkar, Prem M S Chauhan.   

Abstract

A series of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline derivatives has been synthesized and evaluated for antileishmanial activity against Leishmania donovani. Compound 8 exhibited best antileishmanial activity with IC(50) value of 1.93 microg/ml against amastigotes, high selectivity index, and was more active than reference drugs sodium stilbogluconate and pentamidine. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20457476     DOI： 10.1016/j.ejmech.2010.04.004

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  3 in total

1.  An insight into tetrahydro-β-carboline-tetrazole hybrids: synthesis and bioevaluation as potent antileishmanial agents.

Authors:  Pooja Purohit; Anand Kumar Pandey; Deepti Singh; Pradeep Singh Chouhan; Karthik Ramalingam; Mahendra Shukla; Neena Goyal; Jawahar Lal; Prem M S Chauhan
Journal:  Medchemcomm       Date:  2017-07-21       Impact factor: 3.597

2.  Discovery of a tetrazolyl β-carboline with in vitro and in vivo osteoprotective activity under estrogen-deficient conditions.

Authors:  Anirudha Karvande; Shahnawaz Khan; Irfan Khan; Deepti Singh; Vikram Khedgikar; Priyanka Kushwaha; Naseer Ahmad; Priyanka Kothari; Anupam Dhasmana; Ruchir Kant; Ritu Trivedi; Prem M S Chauhan
Journal:  Medchemcomm       Date:  2018-06-12       Impact factor: 3.597

3.  Biological evaluation and structure activity relationship of 9-methyl-1-phenyl-9H-pyrido[3,4-b]indole derivatives as anti-leishmanial agents.

Authors:  Penta Ashok; Subhash Chander; Terry K Smith; Rajnish Prakash Singh; Prabhat Nath Jha; Murugesan Sankaranarayanan
Journal:  Bioorg Chem       Date:  2018-11-22       Impact factor: 5.275
  3 in total

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