Literature DB >> 20456497

Modelling the hair follicle dermal papilla using spheroid cell cultures.

Claire A Higgins, Gavin D Richardson, Dudley Ferdinando, Gillian E Westgate, Colin A B Jahoda.   

Abstract

Human dermal papilla (DP) cells grown in two-dimensional (2D) culture have been studied extensively. However, key differences exist between DP cell activities in vivo and in vitro. Using a suspension method of cell culture to maintain DP cells, we created three-dimensional (3D) dermal spheres morphologically akin to intact (anagen) DPs. Analysis of these spheres using immunocytochemistry demonstrates that they have expression profiles different from papilla cells cultured in 2D but with many similarities to intact DPs. This method of DP cell culture may provide us with a tool to elucidate our understanding of signalling within the DP as it relates to induction, maintenance or even inhibition of hair growth.

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Year:  2010        PMID： 20456497     DOI： 10.1111/j.1600-0625.2009.01007.x

Source DB:  PubMed          Journal:  Exp Dermatol        ISSN： 0906-6705            Impact factor:   3.960


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