Literature DB >> 20456297

A mitochondrial view of aging, reactive oxygen species and metastatic cancer.

Warren Ladiges1, Jonathan Wanagat, Bradley Preston, Lawrence Loeb, Peter Rabinovitch.   

Abstract

This perspective article highlights the growing evidence placing mitochondria and mitochondrial function at the center of cancer as an age-related disease. The discussion starts from the mitochondrial free radical hypothesis that predicts the involvement of endogenous mitochondrial reactive oxygen species (ROS) in cancer development and summarizes studies demonstrating the impact of the modulation of ROS levels on cancer development and metastasis. Cancer is fundamentally a complex interplay of cell growth, division, metastasis and death- processes connected to mitochondria through energy metabolism. Based on this evidence, therapeutics focused on mitochondrial function and mitochondrial ROS production are an attractive approach to modulating the progression of metastatic cancer and the general improvement of human health span.

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Year:  2010        PMID： 20456297     DOI： 10.1111/j.1474-9726.2010.00579.x

Source DB:  PubMed          Journal:  Aging Cell        ISSN： 1474-9718            Impact factor:   9.304


  15 in total

1.  Synthesis of deuterium-labeled analogs of the lipid hydroperoxide-derived bifunctional electrophile 4-oxo-2(E)-nonenal.

Authors:  Jasbir S Arora; Tomoyuki Oe; Ian A Blair
Journal:  J Labelled Comp Radiopharm       Date:  2011-05-15       Impact factor: 1.921

2.  Bioimaging of fluorescence-labeled mitochondria in subcutaneously grafted murine melanoma cells by the "in vivo cryotechnique".

Authors:  Ting Lei; Zheng Huang; Nobuhiko Ohno; Bao Wu; Takashi Sakoh; Yurika Saitoh; Ikuo Saiki; Shinichi Ohno
Journal:  J Histochem Cytochem       Date:  2014-01-06       Impact factor: 2.479

3.  Aging influences cardiac mitochondrial gene expression and cardiovascular function following hemorrhage injury.

Authors:  Bixi Jian; Shaolong Yang; Dongquan Chen; Luyun Zou; John C Chatham; Irshad Chaudry; Raghavan Raju
Journal:  Mol Med       Date:  2010-12-22       Impact factor: 6.354

4.  Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.

Authors:  Yi Wen; Wenjun Li; Ethan C Poteet; Luokun Xie; Cong Tan; Liang-Jun Yan; Xiaohua Ju; Ran Liu; Hai Qian; Marian A Marvin; Matthew S Goldberg; Hua She; Zixu Mao; James W Simpkins; Shao-Hua Yang
Journal:  J Biol Chem       Date:  2011-03-18       Impact factor: 5.157

5.  Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells.

Authors:  Tomoya Kinjo; Jun Ye; Hanxu Yan; Takeki Hamasaki; Hidekazu Nakanishi; Kazuko Toh; Noboru Nakamichi; Shigeru Kabayama; Kiichiro Teruya; Sanetaka Shirahata
Journal:  Cytotechnology       Date:  2012-06-14       Impact factor: 2.058

Review 6.  The role of mitochondrial function and cellular bioenergetics in ageing and disease.

Authors:  M D Brand; A L Orr; I V Perevoshchikova; C L Quinlan
Journal:  Br J Dermatol       Date:  2013-07       Impact factor: 9.302

7.  The role of the mitochondrial genome in ageing and carcinogenesis.

Authors:  Anna M Czarnecka; Ewa Bartnik
Journal:  J Aging Res       Date:  2011-02-15

8.  Mitochondrial targeted catalase suppresses invasive breast cancer in mice.

Authors:  Jorming Goh; Linda Enns; Soroosh Fatemie; Heather Hopkins; John Morton; Christina Pettan-Brewer; Warren Ladiges
Journal:  BMC Cancer       Date:  2011-05-23       Impact factor: 4.430

9.  Breast tumors in PyMT transgenic mice expressing mitochondrial catalase have decreased labeling for macrophages and endothelial cells.

Authors:  Sy Fatemie; Jorming Goh; Christina Pettan-Brewer; Warren Ladiges
Journal:  Pathobiol Aging Age Relat Dis       Date:  2012-05-11

10.  The mitochondrial DNA Northeast Asia CZD haplogroup is associated with good disease-free survival among male oral squamous cell carcinoma patients.

Authors:  Chih-Hsiung Lai; Shiang-Fu Huang; I-How Chen; Chun-Ta Liao; Hung-Ming Wang; Ling-Ling Hsieh
Journal:  PLoS One       Date:  2012-11-21       Impact factor: 3.240
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