BACKGROUND/AIMS: Killer cell immunoglobulin-like receptors (KIR) are involved in the activation/inhibition of NK cells through an interaction with HLA class I molecules on target cells. Our study aimed to evaluate the association between KIR gene polymorphisms and the response of patients with CHC to antiviral therapy. METHODS: We compared the frequency of KIR genes, as well as that of compound KIR/HLA-C genotypes, between groups of patients with CHC who presented a sustained virological response (n=66) and who were non-responders to a combination of pegylated or standard interferon and ribavirin (n=101). KIR and HLA-C genotyping were performed using commercial kits. RESULTS: We detected a greater frequency of the KIR2DL5 gene among non-responders to antiviral therapy compared with sustained virological responders (68.3 vs. 40.9%) (P<0.001). We used multiple logistic regression analysis to determine the association between therapy response and the presence of KIR2DL5, after a control for potentially confounding variables (genotype, alcohol, fibrosis, gender, age, ethnic background and route of HCV infection). The results confirmed the strong association between the presence of KIR2DL5 and the non-response to antiviral treatment (P=0.001). CONCLUSIONS: Host genetic factors may be associated with a non-response to antiviral therapy. KIR2DL5 is a candidate gene involved in immunomodulation associated with non-response to antiviral therapy.
BACKGROUND/AIMS: Killer cell immunoglobulin-like receptors (KIR) are involved in the activation/inhibition of NK cells through an interaction with HLA class I molecules on target cells. Our study aimed to evaluate the association between KIR gene polymorphisms and the response of patients with CHC to antiviral therapy. METHODS: We compared the frequency of KIR genes, as well as that of compound KIR/HLA-C genotypes, between groups of patients with CHC who presented a sustained virological response (n=66) and who were non-responders to a combination of pegylated or standard interferon and ribavirin (n=101). KIR and HLA-C genotyping were performed using commercial kits. RESULTS: We detected a greater frequency of the KIR2DL5 gene among non-responders to antiviral therapy compared with sustained virological responders (68.3 vs. 40.9%) (P<0.001). We used multiple logistic regression analysis to determine the association between therapy response and the presence of KIR2DL5, after a control for potentially confounding variables (genotype, alcohol, fibrosis, gender, age, ethnic background and route of HCV infection). The results confirmed the strong association between the presence of KIR2DL5 and the non-response to antiviral treatment (P=0.001). CONCLUSIONS: Host genetic factors may be associated with a non-response to antiviral therapy. KIR2DL5 is a candidate gene involved in immunomodulation associated with non-response to antiviral therapy.
Authors: Nathan Ford; Catherine Kirby; Kasha Singh; Edward J Mills; Graham Cooke; Adeeba Kamarulzaman; Philipp duCros Journal: Bull World Health Organ Date: 2012-02-03 Impact factor: 9.408
Authors: Mostafa K El Awady; Noha G Bader El Din; Ashraf Tabll; Yaser El Hosary; Ashraf O Abdel Aziz; Hesham El Khayat; Mohsen Salama; Tawfeek H Abdelhafez Journal: World J Gastroenterol Date: 2013-01-14 Impact factor: 5.742
Authors: Jia M Wang; Yong Q Cheng; Lei Shi; Ruo S Ying; Xiao Y Wu; Guang Y Li; Jonathan P Moorman; Zhi Q Yao Journal: J Virol Date: 2013-08-21 Impact factor: 5.103
Authors: Janaina Mota de Vasconcelos; Lizomar de Jesus Maués Pereira Móia; Ivanete do Socorro Abraçado Amaral; Esther Castello Branco Mello Miranda; Louise Yukari Cicalisetakeshita; Layanna Freitas de Oliveira; Lilian de Araújo Melo Mendes; Danuta Sastre; Bruna Pedroso Tamegão-Lopes; Larysse Santa Rosa de Aquino Pedroza; Sidney Emanuel Batista Dos Santos; Manoel do Carmo Pereira Soares; Marialva Tereza Ferreira de Araújo; Camila Lucas Bandeira; Adriana Maria Paixão de Sousa da Silva; Zilene Lameira de Medeiros; Leonardo Sena; Samia Demachki; Eduardo José Melo Dos Santos Journal: Genet Mol Biol Date: 2013-03-04 Impact factor: 1.771