| Literature DB >> 20455662 |
Eva Horvath1, Claire I Coire, Kalman Kovacs, Harley S Smyth.
Abstract
Two unique, formerly unrecorded sellar neoplasms were observed in two women of 60 and 63 years of age. One lesion consisted of small epithelial cells and the other was a large-cell oncocytic tumor, yet they had the same simple cytoplasmic organization with dominance of polyribosomes and a sprinkle of glycogen. Striking markers shared by the neoplasms: (1) network of typical pituitary follicles, and (2) unexpected similarity to fetal human pituitary tissue at different gestational ages of 6 and 10-12 weeks. The latter showed appreciable endocrine differentiation. The assumed parent cell is the folliculo-stellate cell as pluripotent adult stem cell.Entities:
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Year: 2010 PMID： 20455662 DOI： 10.3109/01913121003662247
Source DB: PubMed Journal: Ultrastruct Pathol ISSN： 0191-3123 Impact factor: 1.094