Literature DB >> 2045546

Species variation in organellar location and activity of L-pipecolic acid oxidation in mammals.

S J Mihalik1, W J Rhead.   

Abstract

The oxidation of L-pipecolic acid to alpha-aminoadipic acid was studied in eight species of mammals using an assay system more sensitive than those previously employed. After percoll-gradient fractionation, activity was localized to the mitochondrial-enriched fractions in tissues from rabbit, guinea pig, pig, dog, and sheep, with guinea pig kidney cortex showing greatest specific activity. These results contrast with the peroxisomal oxidation of L-pipecolic acid observed in macaques and man (Mihalik and Rhead 1989; Mihalik et al. 1989). Rats and mice had undetectable levels of both peroxisomal and mitochondrial L-pipecolic acid oxidation. In the rat, peroxisomal oxidation activity was not induced by feeding with either clofibrate or clofibrate and L-pipecolic acid. Thus, among mammals, both the ability to oxidize L-pipecolic acid and the organellar location of this oxidation is species dependent.

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Year:  1991        PMID： 2045546     DOI： 10.1007/bf00571266

Source DB:  PubMed          Journal:  J Comp Physiol B        ISSN： 0174-1578            Impact factor:   2.200


  31 in total

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Authors:  Y E Chang
Journal:  J Neurochem       Date:  1978-02       Impact factor: 5.372

5.  Pipecolic acid is oxidized by renal and hepatic peroxisomes. Implications for Zellweger's cerebro-hepato-renal syndrome (CHRS).

Authors:  K Zaar; S Angermüller; A Völkl; H D Fahimi
Journal:  Exp Cell Res       Date:  1986-05       Impact factor: 3.905

6.  Hyperpipecolic acidemia: clinical and biochemical observations in two male siblings.

Authors:  B K Burton; S P Reed; W T Remy
Journal:  J Pediatr       Date:  1981-11       Impact factor: 4.406

7.  Hepatic enzymes, CoASH and long-chain acyl-CoA in subcellular fractions as affected by drugs inducing peroxisomes and smooth endoplasmic reticulum.

Authors:  R K Berge; A Aarsland; O M Bakke; M Farstad
Journal:  Int J Biochem       Date:  1983

8.  Hyperpipecolic acidemia in neonatal adrenoleukodystrophy.

Authors:  R I Kelley; H W Moser
Journal:  Am J Med Genet       Date:  1984-12

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Authors:  S Lam; J Hutzler; J Dancis
Journal:  Biochim Biophys Acta       Date:  1986-06-19

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Authors:  S Goldfischer; J Collins; I Rapin; B Coltoff-Schiller; C H Chang; M Nigro; V H Black; N B Javitt; H W Moser; P B Lazarow
Journal:  Science       Date:  1985-01-04       Impact factor: 47.728
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  5 in total

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Authors:  Roland Posset; Silvana Opp; Eduard A Struys; Alfred Völkl; Heribert Mohr; Georg F Hoffmann; Stefan Kölker; Sven W Sauer; Jürgen G Okun
Journal:  J Inherit Metab Dis       Date:  2014-09-12       Impact factor: 4.982

5.  The mitochondrial pool of free amino acids reflects the composition of mitochondrial DNA-encoded proteins: indication of a post- translational quality control for protein synthesis.

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