Theodor C Sauer1, Sanford M Meyers, Defen Shen, Sara Vegh, Charles Vygantas, Chi-Chao Chan. 1. From the *Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland; †Retina Consultants, Des Plaines, Illinois; and ‡Retina Consultants, Libertyville, Illinois.
Abstract
PURPOSE: Toxoplasmosis gondii is a common worldwide parasite that presents in the eye with focal retinochoriditis and vitritis. Although it is rare, ocular toxoplasmosis has been linked to primary intraocular (retinal) lymphoma, which is mostly a diffuse large B-cell lymphoma. METHODS: An elderly female patient was treated for recurrent ocular toxoplasmosis, and because of progressive vitritis, a diagnostic vitrectomy was performed. Shortly afterward, she developed multiple brain lesions. Pathologic examinations of the vitreous specimen and cerebral tissues were conducted, including tests for T. gondii, Epstein-Barr virus, and cytomegalovirus DNA. RESULTS: The patient initially responded to antitoxoplasmosis treatment but continued to have persistent vitritis. She was diagnosed with primary intraocular lymphoma, and a repeated magnetic resonance imaging revealed cerebral lesions. Brain biopsy confirmed lymphoma. T. gondii DNA was found in malignant vitreous cells but was absent in the nonmalignant vitreous cells and brain lymphoma cells. The cytomegalovirus and Epstein-Barr virus genes were not found in any of the lymphoma cells. CONCLUSION: T. gondii may have played a role in lymphoproliferation and primary intraocular lymphoma development.
PURPOSE:Toxoplasmosis gondii is a common worldwide parasite that presents in the eye with focal retinochoriditis and vitritis. Although it is rare, ocular toxoplasmosis has been linked to primary intraocular (retinal) lymphoma, which is mostly a diffuse large B-cell lymphoma. METHODS: An elderly female patient was treated for recurrent ocular toxoplasmosis, and because of progressive vitritis, a diagnostic vitrectomy was performed. Shortly afterward, she developed multiple brain lesions. Pathologic examinations of the vitreous specimen and cerebral tissues were conducted, including tests for T. gondii, Epstein-Barr virus, and cytomegalovirus DNA. RESULTS: The patient initially responded to antitoxoplasmosis treatment but continued to have persistent vitritis. She was diagnosed with primary intraocular lymphoma, and a repeated magnetic resonance imaging revealed cerebral lesions. Brain biopsy confirmed lymphoma. T. gondii DNA was found in malignant vitreous cells but was absent in the nonmalignant vitreous cells and brain lymphoma cells. The cytomegalovirus and Epstein-Barr virus genes were not found in any of the lymphoma cells. CONCLUSION:T. gondii may have played a role in lymphoproliferation and primary intraocular lymphoma development.
Authors: P Ryan; S F Hurley; A M Johnson; M Salzberg; M W Lee; J B North; J J McNeil; A J McMichael Journal: Int J Epidemiol Date: 1993-06 Impact factor: 7.196
Authors: S M Whitcup; M D de Smet; B I Rubin; A G Palestine; D F Martin; M Burnier; C C Chan; R B Nussenblatt Journal: Ophthalmology Date: 1993-09 Impact factor: 12.079
Authors: Huân M Ngô; Ying Zhou; Hernan Lorenzi; Kai Wang; Taek-Kyun Kim; Yong Zhou; Kamal El Bissati; Ernest Mui; Laura Fraczek; Seesandra V Rajagopala; Craig W Roberts; Fiona L Henriquez; Alexandre Montpetit; Jenefer M Blackwell; Sarra E Jamieson; Kelsey Wheeler; Ian J Begeman; Carlos Naranjo-Galvis; Ney Alliey-Rodriguez; Roderick G Davis; Liliana Soroceanu; Charles Cobbs; Dennis A Steindler; Kenneth Boyer; A Gwendolyn Noble; Charles N Swisher; Peter T Heydemann; Peter Rabiah; Shawn Withers; Patricia Soteropoulos; Leroy Hood; Rima McLeod Journal: Sci Rep Date: 2017-09-13 Impact factor: 4.379