Literature DB >> 20454527

On Asymptotically Optimal Tests Under Loss of Identifiability in Semiparametric Models.

Rui Song1, Michael R Kosorok, Jason P Fine.   

Abstract

We consider tests of hypotheses when the parameters are not identifiable under the null in semiparametric models, where regularity conditions for profile likelihood theory fail. Exponential average tests based on integrated profile likelihood are constructed and shown to be asymptotically optimal under a weighted average power criterion with respect to a prior on the nonidentifiable aspect of the model. These results extend existing results for parametric models, which involve more restrictive assumptions on the form of the alternative than do our results. Moreover, the proposed tests accommodate models with infinite dimensional nuisance parameters which either may not be identifiable or may not be estimable at the usual parametric rate. Examples include tests of the presence of a change-point in the Cox model with current status data and tests of regression parameters in odds-rate models with right censored data. Optimal tests have not previously been studied for these scenarios. We study the asymptotic distribution of the proposed tests under the null, fixed contiguous alternatives and random contiguous alternatives. We also propose a weighted bootstrap procedure for computing the critical values of the test statistics. The optimal tests perform well in simulation studies, where they may exhibit improved power over alternative tests.

Entities:  

Year:  2009        PMID: 20454527      PMCID: PMC2864541          DOI: 10.1214/08-aos643

Source DB:  PubMed          Journal:  Ann Stat        ISSN: 0090-5364            Impact factor:   4.028


  4 in total

1.  Generalized proportional hazards model based on modified partial likelihood.

Authors:  V B Bagdonavicius; M S Nikulin
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2.  Comparison of maximum statistics for hypothesis testing when a nuisance parameter is present only under the alternative.

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Journal:  Biometrics       Date:  2005-03       Impact factor: 2.571

3.  Semiparametric efficient estimation in the generalized odds-rate class of regression models for right-censored time-to-event data.

Authors:  D O Scharfstein; A A Tsiatis; P B Gilbert
Journal:  Lifetime Data Anal       Date:  1998       Impact factor: 1.588

4.  Fitting bent lines to data, with applications to allometry.

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Journal:  J Theor Biol       Date:  1989-05-22       Impact factor: 2.691

  4 in total
  4 in total

1.  A sup-score test for the cure fraction in mixture models for long-term survivors.

Authors:  Wei-Wen Hsu; David Todem; KyungMann Kim
Journal:  Biometrics       Date:  2016-04-14       Impact factor: 2.571

2.  On pseudolikelihood inference for semiparametric models with boundary problems.

Authors:  Y Chen; J Ning; Y Ning; K-Y Liang; K Bandeen-Roche
Journal:  Biometrika       Date:  2017-02-18       Impact factor: 2.445

3.  A quasi-score statistic for homogeneity testing against covariate-varying heterogeneity.

Authors:  David Todem; Wei-Wen Hsu; Jason P Fine
Journal:  Scand Stat Theory Appl       Date:  2017-12-14       Impact factor: 1.396

4.  Evaluating Statistical Hypotheses Using Weakly-Identifiable Estimating Functions.

Authors:  Guanqun Cao; David Todem; Lijian Yang; Jason P Fine
Journal:  Scand Stat Theory Appl       Date:  2013-06-01       Impact factor: 1.396

  4 in total

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