| Literature DB >> 20452834 |
Marjan Nassiri-Asl1, Seyed-Reza Mortazavi, Fatemeh Samiee-Rad, Amir-Abdollah Zangivand, Freshteh Safdari, Sepideh Saroukhani, Esmail Abbasi.
Abstract
Individuals with epilepsy often complain about memory deficits. Various synthetic derivatives of natural flavonoids are known to have neuroactive properties. Rutin is a flavonoid that is an important dietary constituent of foods and plant-based beverages. The aim of the present study was to investigate the effects of rutin on memory retrieval in pentylenetetrazole (PTZ)-kindled rats using a step-through passive avoidance task. We administered rutin and PTZ intraperitoneally every other day prior to the start of training. Two retention tests were subsequently performed to assess memory in these rats. The results suggest that pretreatment with rutin at 50 and 100mg/kg can attenuate seizure severity during the kindling procedure. Furthermore, rutin administration significantly increased the step-through latency in the passive avoidance paradigm. Taken together, these results indicate that rutin has a potential role in enhancing memory retrieval in kindled rats. Copyright (c) 2010 Elsevier Inc. All rights reserved.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20452834 DOI： 10.1016/j.yebeh.2010.03.005
Source DB: PubMed Journal: Epilepsy Behav ISSN： 1525-5050 Impact factor: 2.937