| Literature DB >> 20452351 |
Myrna A R Dent1, Edith Segura-Anaya, Janeth Alva-Medina, Armando Aranda-Anzaldo.
Abstract
NeuN is an antigen detected in the nucleus of neurons in a wide range of vertebrates and so it is widely used as a tool for detecting neuronal cells. NeuN has been recently identified as Fox-3, a new member of the Fox-1 gene family of splicing factors. The predominant localization of NeuN/Fox-3 to neuronal nuclei and its role in splicing pose the question of the nuclear compartmentalization of such a protein. Here we provide evidence that NeuN/Fox-3 is an intrinsic component of the neuronal nuclear matrix and a reliable marker of nuclear speckles in neurons. Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20452351 DOI： 10.1016/j.febslet.2010.04.073
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124