Literature DB >> 20452350

Transforming growth factor-beta inhibits nephronectin-induced osteoblast differentiation.

Ling Fang1, Shireen Kahai, Weining Yang, Chengyan He, Arun Seth, Chun Peng, Burton B Yang.   

Abstract

We used cDNA microarray to identify transforming growth factor beta (TGF-beta) responsive target genes during osteoblast development and found that nephronectin (Npnt) is one such gene that is significantly down-regulated. Here we report the role of TGF-beta in regulating Npnt-mediated osteoblast differentiation. We found that the effect of TGF-beta on Npnt expression is associated with a change in cell morphology in a dose-dependent manner. Npnt-induced osteoblast differentiation was also inhibited by TGF-beta, which changed cell morphology from cuboidal to fibroblastic, an indication that osteoblast differentiation was disrupted. Furthermore, TGF-beta inhibited differentiation of osteoblasts transfected with various truncated Npnt constructs, suggesting that TGF-beta can exert a down-stream effect on Npnt function. Our results suggest that TGF-beta can inhibit osteoblast differentiation through various mechanisms. Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20452350     DOI： 10.1016/j.febslet.2010.04.074

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Podocytes regulate the glomerular basement membrane protein nephronectin by means of miR-378a-3p in glomerular diseases.

Authors:  Janina Müller-Deile; Jan Dannenberg; Patricia Schroder; Meei-Hua Lin; Jeffrey H Miner; Rongjun Chen; Jan-Hinrich Bräsen; Thomas Thum; Jenny Nyström; Lynne Beverly Staggs; Hermann Haller; Jan Fiedler; Johan M Lorenzen; Mario Schiffer
Journal:  Kidney Int       Date:  2017-05-03       Impact factor: 10.612

2.  Expression of versican 3'-untranslated region modulates endogenous microRNA functions.

Authors:  Daniel Y Lee; Zina Jeyapalan; Ling Fang; Jennifer Yang; Yaou Zhang; Albert Y Yee; Minhui Li; William W Du; Tatiana Shatseva; Burton B Yang
Journal:  PLoS One       Date:  2010-10-25       Impact factor: 3.240

3.  Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish.

Authors:  Chinmoy Patra; Florian Diehl; Fulvia Ferrazzi; Machteld J van Amerongen; Tatyana Novoyatleva; Liliana Schaefer; Christian Mühlfeld; Benno Jungblut; Felix B Engel
Journal:  Development       Date:  2011-10       Impact factor: 6.868

4.  Ccn2a is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish.

Authors:  Debanjan Mukherjee; Ganesh Wagh; Mayssa H Mokalled; Zacharias Kontarakis; Amy L Dickson; Amey Rayrikar; Stefan Günther; Kenneth D Poss; Didier Y R Stainier; Chinmoy Patra
Journal:  Development       Date:  2021-01-18       Impact factor: 6.862

5.  Expression of nephronectin is inhibited by oncostatin M via both JAK/STAT and MAPK pathways.

Authors:  Tamaki Kurosawa; Atsushi Yamada; Masamichi Takami; Dai Suzuki; Yoshiro Saito; Katsuhiro Hiranuma; Takuya Enomoto; Naoko Morimura; Matsuo Yamamoto; Takehiko Iijima; Tatsuo Shirota; Hiroyuki Itabe; Ryutaro Kamijo
Journal:  FEBS Open Bio       Date:  2015-04-08       Impact factor: 2.693

6.  NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase.

Authors:  Vincent Kuek; Zhifan Yang; Shek Man Chim; Sipin Zhu; Huazi Xu; Siu To Chow; Jennifer Tickner; Vicki Rosen; Wendy Erber; Xiucheng Li; An Qin; Yu Qian; Jiake Xu
Journal:  Sci Rep       Date:  2016-10-26       Impact factor: 4.379

7.  Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development.

Authors:  Justin Ma; Lian Bi; James Spurlin; Peter Lwigale
Journal:  Elife       Date:  2022-03-03       Impact factor: 8.140
  7 in total

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