| Literature DB >> 20452225 |
Marc Lamblin1, Basel Dabbas, Russell Spingarn, Rodrigo Mendoza-Sanchez, Tian-Tian Wang, Beum-Soo An, Dao Chao Huang, Richard Kremer, John H White, James L Gleason.
Abstract
Incorporation of zinc-binding groups into the side-chain of 1alpha,25-dihydroxyvitamin D(3) (1,25D) fully bifunctional hybrid molecules which act both as vitamin D receptor agonists and histone deacetylase inhibitors. These bifunctional hybrids display in vitro antiproliferative activity against the AT84 squamous carcinoma cell line while lacking the in vivo hypercalcemic effects of 1,25D.Entities:
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Year: 2010 PMID： 20452225 DOI： 10.1016/j.bmc.2010.03.078
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641