| Literature DB >> 20452220 |
Deilson Elgui de Oliveira1, Gianna Ballon, Ethel Cesarman.
Abstract
The nuclear factor (NF)-kappaB signaling pathway is pivotal for immune system function. Not surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two examples are Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), oncogenic gammaherpesviruses that establish a lifelong latent infection in their human hosts. The modulation of NF-kappaB signaling by EBV and KSHV is not only important for viral infection, but also contributes to the development of malignant neoplasia. This review explores the current knowledge of NF-kappaB modulation by EBV and KSHV, focusing on connections between viral biology and human carcinogenesis. Copyright 2010. Published by Elsevier Ltd.Entities:
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Year: 2010 PMID: 20452220 DOI: 10.1016/j.tim.2010.04.001
Source DB: PubMed Journal: Trends Microbiol ISSN: 0966-842X Impact factor: 17.079