Amanda M Kalan1, Hyagriv N Simhan. 1. Department of Obstetrics and Gynecology, Magee Womens Hospital, Pittsburgh, PA 15213, USA.
Abstract
OBJECTIVE: The purpose of this study was to explore the relation between the relative balance of pro- and antiinflammatory cytokines in cervical fluid and mid-trimester cervical length. STUDY DESIGN: In this prospective longitudinal cohort of women with a previous spontaneous preterm birth, mid-trimester cervical length ultrasound scans and cervical fluid levels were obtained serially. Multiple pro- and antiinflammatory cytokines were selected. We summed the multiples of the median for proinflammatory cytokines to generate the proinflammatory and the antiinflammatory scores. The relation between cervical length and pro-/antiinflammatory ratio was assessed by generalized estimating equations. RESULTS: The pro-/antiinflammatory ratio had a negative linear association with cervical length (beta = -0.09; P < .001). Sixty percent of visits demonstrated greater concentrations of proinflammatory cytokines relative to antiinflammatory cytokines. This relationship did not change between first and last visits. CONCLUSION: Among women with a previous preterm birth, shorter mid-trimester cervical length is associated with a more proinflammatory balance of cytokines in the cervical inflammatory milieu. Copyright (c) 2010 Mosby, Inc. All rights reserved.
OBJECTIVE: The purpose of this study was to explore the relation between the relative balance of pro- and antiinflammatory cytokines in cervical fluid and mid-trimester cervical length. STUDY DESIGN: In this prospective longitudinal cohort of women with a previous spontaneous preterm birth, mid-trimester cervical length ultrasound scans and cervical fluid levels were obtained serially. Multiple pro- and antiinflammatory cytokines were selected. We summed the multiples of the median for proinflammatory cytokines to generate the proinflammatory and the antiinflammatory scores. The relation between cervical length and pro-/antiinflammatory ratio was assessed by generalized estimating equations. RESULTS: The pro-/antiinflammatory ratio had a negative linear association with cervical length (beta = -0.09; P < .001). Sixty percent of visits demonstrated greater concentrations of proinflammatory cytokines relative to antiinflammatory cytokines. This relationship did not change between first and last visits. CONCLUSION: Among women with a previous preterm birth, shorter mid-trimester cervical length is associated with a more proinflammatory balance of cytokines in the cervical inflammatory milieu. Copyright (c) 2010 Mosby, Inc. All rights reserved.
Authors: Jeny P Ghartey; Colleen Carpenter; Philip Gialanella; Charlotte Rising; Thomas C McAndrew; Mohak Mhatre; Jessica Tugetman; Mark H Einstein; Cynthia Chazotte; Betsy C Herold Journal: Am J Obstet Gynecol Date: 2012-07-26 Impact factor: 8.661
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