Literature DB >> 20451497

Altered microRNAs in STHdh(Q111)/Hdh(Q111) cells: miR-146a targets TBP.

Mithun Sinha1, Jayeeta Ghose, Eashita Das, Nitai P Bhattarcharyya.   

Abstract

We studied expression of 90 miRNAs in STHdh(Q111)/Hdh(Q111) cells, a model for Huntington's disease and compared with that obtained in STHdh(Q7)/Hdh(Q7) cells. Fifteen miRNAs were down regulated and 12 miRNAs were up regulated more than 2-fold. Such changes were statistically significant. One hundred and forty-two genes are experimentally known targets of these altered miRNAs. It has been predicted that miR-146a may target Tata Binding Protein (TBP). Using luciferase reporter assays with 3'-UTRs of TBP, over-expression and inhibition of miR-146a, we showed that miR-146a targets TBP. Regulation of TBP by miR-146a may contribute to HD pathogenesis. Copyright (c) 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20451497     DOI： 10.1016/j.bbrc.2010.05.007

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  29 in total

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