Literature DB >> 2045104

Linear order of new and established DNA markers around the fragile site at Xq27.3.

M C Hirst1, A Roche, T J Flint, R N MacKinnon, J H Bassett, Y Nakahori, J E Watson, M V Bell, M N Patterson, Y Boyd.   

Abstract

We have used recombinant clones derived from microdissection of the fragile X region to characterize breakpoints around the fragile site at Xq27.3. So far, no microdissection markers derived from Xq28 material have been found, thus allowing a rapid screening for clones surrounding the fragile site by their presence in a somatic cell hybrid containing Xq27.2-Xqter. A total of 43 new DNA markers from Xq27 have been sublocalized within this chromosome band. Of these new DNA markers, 5 lie in an interval defined as containing the fragile X region. The saturation of Xq27 with DNA markers by microdissection demonstrates the power of this technique and provides the resources for generating a complete physical map of the region.

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Year:  1991        PMID： 2045104     DOI： 10.1016/0888-7543(91)90506-a

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  8 in total

Review 1.  Molecular analysis of the fragile X syndrome.

Authors:  M C Hirst; S M Knight; Y Nakahori; A Roche; K E Davies
Journal:  J Inherit Metab Dis       Date:  1992       Impact factor: 4.982

2.  A YAC contig across the fragile X site defines the region of fragility.

Authors:  M C Hirst; K Rack; Y Nakahori; A Roche; M V Bell; G Flynn; Z Christadoulou; R N MacKinnon; M Francis; A J Littler
Journal:  Nucleic Acids Res       Date:  1991-06-25       Impact factor: 16.971

Review 3.  Long-range walking techniques in positional cloning strategies.

Authors:  L Stubbs
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

4.  A microdeletion of less than 250 kb, including the proximal part of the FMR-I gene and the fragile-X site, in a male with the clinical phenotype of fragile-X syndrome.

Authors:  D Wöhrle; D Kotzot; M C Hirst; A Manca; B Korn; A Schmidt; G Barbi; H D Rott; A Poustka; K E Davies
Journal:  Am J Hum Genet       Date:  1992-08       Impact factor: 11.025

5.  Evaluation of human microdissection clones from the FRAXA region as tools for comparative mapping in the mouse: isolation of a conserved genomic clone close to FMR1.

Authors:  H J Blair; M C Hirst; R MacKinnon; K E Davies; Y Boyd
Journal:  Mamm Genome       Date:  1994-09       Impact factor: 2.957

Review 6.  The fragile X syndrome: isolation of the FMR-1 gene and characterization of the fragile X mutation.

Authors:  B A Oostra; A J Verkerk
Journal:  Chromosoma       Date:  1992-04       Impact factor: 4.316

7.  Molecular heterogeneity of the fragile X syndrome.

Authors:  Y Nakahori; S J Knight; J Holland; C Schwartz; A Roche; J Tarleton; S Wong; T J Flint; U Froster-Iskenius; D Bentley
Journal:  Nucleic Acids Res       Date:  1991-08-25       Impact factor: 16.971

8.  Myotubular myopathy in a girl with a deletion at Xq27-q28 and unbalanced X inactivation assigns the MTM1 gene to a 600-kb region.

Authors:  N Dahl; L J Hu; M Chery; M Fardeau; S Gilgenkrantz; A Nivelon-Chevallier; I Sidaner-Noisette; F Mugneret; J B Gouyon; A Gal
Journal:  Am J Hum Genet       Date:  1995-05       Impact factor: 11.025
  8 in total

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