Literature DB >> 204509

Effect of carbenoxolone on phosphodiesterase and prostaglandin synthetase activities.

H Vapaatalo, I B Lindén, T Metsä-Ketelä, M Kangasaho, K Laustiola.   

Abstract

Carbenoxolone inhibited in vitro cAMP and cGMP phosphodiesterases in a concentration-dependent and noncompetitive manner. Prostaglandin synthetase activity of rabbit kidney medulla was slightly stimulated by carbenoxolone 0.1--0.5 mM, but inhibited by higher concentrations.

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Year:  1978        PMID： 204509     DOI： 10.1007/bf01923050

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  A sensitive biological assay for prostaglandin E and acetylcholine.

Authors:  H Vapaatalo; I B Lindén; J Parantainen
Journal:  J Pharm Pharmacol       Date:  1976-03       Impact factor: 3.765

2.  Cyclic GMP response in vivo to cholinergic stimulation of gastric mucosa.

Authors:  J H Eichhorn; E W Salzman; W Silen
Journal:  Nature       Date:  1974-03-15       Impact factor: 49.962

3.  Letter: Cyclic GMP and gastric acid secretion.

Authors:  R H Bower; J Sode; W Lipshutz
Journal:  Am J Dig Dis       Date:  1974-06

4.  Failure of pentagastrin to stimulate cyclic AMP accumulation in human gastric mucosa.

Authors:  W Domschke; S Domschke; W Rösch; M Classen; L Demling
Journal:  Scand J Gastroenterol       Date:  1974       Impact factor: 2.423

Review 5.  Cyclic GMP and gastric acid secretion.

Authors:  M S Amer
Journal:  Am J Dig Dis       Date:  1974-01

6.  Multiple cyclic nucleotide phosphodiesterase activities from rat brain.

Authors:  W J Thompson; M M Appleman
Journal:  Biochemistry       Date:  1971-01-19       Impact factor: 3.162

7.  Inhibitory effect of prostaglandins on isosmotic fluid transport by rabbit gall-bladder in vitro, and its modification by blocade of endogenous PGE-Biosynthesis with indomethacin.

Authors:  P P Leyssac; K Bukhave; O Frederiksen
Journal:  Acta Physiol Scand       Date:  1974-12

Review 8.  Cyclic nucleotides and their role in gastrointestinal secretion.

Authors:  D V Kimbert
Journal:  Gastroenterology       Date:  1974-11       Impact factor: 22.682

9.  Effect of glycyrrhetinic acid on the cyclic nucleotide system of the rat stomach.

Authors:  M S Amer; G R McKinney; A Akcasu
Journal:  Biochem Pharmacol       Date:  1974-11-15       Impact factor: 5.858

10.  Morphological observations on gastric ulcers treated with carbenoxolone sodium.

Authors:  T E Goodier; L Horwich; R W Galloway
Journal:  Gut       Date:  1967-12       Impact factor: 23.059
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  3 in total

1.  Effect of carbenoxolone on the biological activity of nitric oxide: relation to gastroprotection.

Authors:  A Dembinska-Kiec; D Pallapies; T Simmet; B M Peskar; B A Peskar
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

2.  Role of endothelial cell hyperpolarization in EDHF-mediated responses in the guinea-pig carotid artery.

Authors:  J F Quignard; M Félétou; G Edwards; J Duhault; A H Weston; P M Vanhoutte
Journal:  Br J Pharmacol       Date:  2000-03       Impact factor: 8.739

3.  Carbenoxolone and deglycyrrhized liquorice have little or no effect on prostanoid synthesis by rat gastric mucosa ex vivo.

Authors:  A Bennett; P B Melhuish; I F Stamford
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739
  3 in total

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