BACKGROUND: Secondary thrombocytosis is associated with a variety of clinical conditions, one of which is lower respiratory tract infection. However, reports on thrombocytosis induced by viral infections are scarce. OBJECTIVES: To assess the rate of thrombocytosis (platelet count > 500 x 10(9)/L) in hospitalized infants with bronchiolitis and to investigate its potential role as an early marker of respiratory syncytial virus infection. METHODS: Clinical data on 469 infants aged < or = 4 months who were hospitalized for bronchiolitis were collected prospectively and compared between RSV-positive and RSV-negative infants. RESULTS: The rate of thrombocytosis was significantly higher in RSV-positive than RSV-negative infants (41.3% vs. 29.2%, P=0.031). The odds ratio of an infant with bronchiolitis and thrombocytosis to have a positive RSV infection compared to an infant with bronchiolitis and a normal platelet count was 1.7 (P= 0.023, 95% confidence interval 1.07-2.72). There was no significant difference in mean platelet count between the two groups. CONCLUSIONS: RSV-positive bronchiolitis in hospitalized young infants is associated with thrombocytosis.
BACKGROUND: Secondary thrombocytosis is associated with a variety of clinical conditions, one of which is lower respiratory tract infection. However, reports on thrombocytosis induced by viral infections are scarce. OBJECTIVES: To assess the rate of thrombocytosis (platelet count > 500 x 10(9)/L) in hospitalized infants with bronchiolitis and to investigate its potential role as an early marker of respiratory syncytial virus infection. METHODS: Clinical data on 469 infants aged < or = 4 months who were hospitalized for bronchiolitis were collected prospectively and compared between RSV-positive and RSV-negative infants. RESULTS: The rate of thrombocytosis was significantly higher in RSV-positive than RSV-negative infants (41.3% vs. 29.2%, P=0.031). The odds ratio of an infant with bronchiolitis and thrombocytosis to have a positive RSV infection compared to an infant with bronchiolitis and a normal platelet count was 1.7 (P= 0.023, 95% confidence interval 1.07-2.72). There was no significant difference in mean platelet count between the two groups. CONCLUSIONS: RSV-positive bronchiolitis in hospitalized young infants is associated with thrombocytosis.
Authors: Amar Al Shibli; Najla Alkuwaiti; May Hamie; Dima Abukhater; Muhammad B Noureddin; Abdulla Amri; Salwa Al Kaabi; Aysha Al Kaabi; Mariam Harbi; Hassib Narchi Journal: World J Clin Pediatr Date: 2017-05-08
Authors: Ioannis N Mammas; Simon B Drysdale; Barbara Rath; Maria Theodoridou; Georgia Papaioannou; Alexia Papatheodoropoulou; Eirini Koutsounaki; Chryssie Koutsaftiki; Eleftheria Kozanidou; Vassilis Achtsidis; Paraskevi Korovessi; George P Chrousos; Demetrios A Spandidos Journal: Int J Mol Med Date: 2020-06-15 Impact factor: 4.101