BACKGROUND: The incidence of congenital heart defects, reported to be 5-8/1000 in term infants, is not well established in very low birth weight infants. OBJECTIVES: To establish the incidence of congenital heart defects in VLBW infants in the neonatal intensive care unit of our institution. METHODS: A retrospective analysis of the population in the NICU at our institution was performed. VLBW (BW < or = 1500 g) infants born between 2001 and 2006 who survived more than 48 hours were included in the study. Infants with clinical signs of heart disease underwent echocardiography. RESULTS: During the study period 437 VLBW live-born infants met the inclusion criteria. Of these, 281 (64.3%) underwent echocardiography. CHD was detected in 19 infants (4.4%, 95% confidence interval 2.4-5.4%), significantly higher than the incidence of 5-8/1000 in the general population (P<0.0001). In the subgroup of 154 infants with BW < 1000 g there were 10 (6.5%) with CHD. In the subgroup of 283 infants with BW 100-1500 g there were 9 (3.2%, P= 0.19 vs. VLBW) with CHD. CONCLUSIONS: Our observations show an increased incidence of CHD in VLBW neonates, as compared to the general population. Since not all infants underwent echocardiography, and minor cardiac defects may have been missed in our VLBW infants, the true incidence may be higher than reported here.
BACKGROUND: The incidence of congenital heart defects, reported to be 5-8/1000 in term infants, is not well established in very low birth weight infants. OBJECTIVES: To establish the incidence of congenital heart defects in VLBW infants in the neonatal intensive care unit of our institution. METHODS: A retrospective analysis of the population in the NICU at our institution was performed. VLBW (BW < or = 1500 g) infants born between 2001 and 2006 who survived more than 48 hours were included in the study. Infants with clinical signs of heart disease underwent echocardiography. RESULTS: During the study period 437 VLBW live-born infants met the inclusion criteria. Of these, 281 (64.3%) underwent echocardiography. CHD was detected in 19 infants (4.4%, 95% confidence interval 2.4-5.4%), significantly higher than the incidence of 5-8/1000 in the general population (P<0.0001). In the subgroup of 154 infants with BW < 1000 g there were 10 (6.5%) with CHD. In the subgroup of 283 infants with BW 100-1500 g there were 9 (3.2%, P= 0.19 vs. VLBW) with CHD. CONCLUSIONS: Our observations show an increased incidence of CHD in VLBW neonates, as compared to the general population. Since not all infants underwent echocardiography, and minor cardiac defects may have been missed in our VLBW infants, the true incidence may be higher than reported here.
Authors: Athina Pappas; Seetha Shankaran; Nellie I Hansen; Edward F Bell; Barbara J Stoll; Abbot R Laptook; Michele C Walsh; Abhik Das; Rebecca Bara; Ellen C Hale; Nancy S Newman; Nansi S Boghossian; Jeffrey C Murray; C Michael Cotten; Ira Adams-Chapman; Shannon Hamrick; Rosemary D Higgins Journal: Pediatr Cardiol Date: 2012-05-30 Impact factor: 1.655
Authors: Angelo Polito; Simone Piga; Paola E Cogo; Carlo Corchia; Virgilio Carnielli; Monica Da Frè; Domenico Di Lallo; Isabella Favia; Luigi Gagliardi; Francesco Macagno; Silvana Miniaci; Marina Cuttini Journal: Intensive Care Med Date: 2013-03-28 Impact factor: 17.440
Authors: Anna W Anderson; P Brian Smith; Kristin M Corey; Kevin D Hill; Kanecia O Zimmerman; Reese H Clark; Christoph P Hornik Journal: Early Hum Dev Date: 2014-10-16 Impact factor: 2.699
Authors: Mikael Norman; Stellan Håkansson; Satoshi Kusuda; Maximo Vento; Liisa Lehtonen; Brian Reichman; Brian A Darlow; Mark Adams; Dirk Bassler; Tetsuya Isayama; Franca Rusconi; Shoo Lee; Kei Lui; Junmin Yang; Prakesh S Shah Journal: J Am Heart Assoc Date: 2020-02-21 Impact factor: 5.501