OBJECTIVE: Neurologic outcome after cardiopulmonary resuscitation from cardiac arrest carries a poor prognosis and treatment options to ameliorate brain damage are limited. DESIGN: Report of two protocols investigating the effects of xenon (Xe) and isoflurane (Iso) in a porcine model of prolonged cardiac arrest and subsequent cardiopulmonary resuscitation on functional neurologic outcomes. SETTING: Prospective, randomized, laboratory animal study. SUBJECTS: Male domestic pigs (Sus scrofa). INTERVENTIONS: After successful resuscitation from 8 mins of cardiac arrest and 5 mins of cardiopulmonary resuscitation, pigs were randomized to receive either Xe for 1 or 5 hrs in comparison with untreated controls 1 hr after cardiopulmonary resuscitation (protocol 1) or to receive Iso or Xe in comparison with untreated controls 10 mins after cardiopulmonary resuscitation (protocol 2). MEASUREMENTS AND MAIN RESULTS: Animals were exposed to an established cognitive function test and gross neurologic performance was assessed using a neurologic deficit score. In protocol 1, Xe administration resulted in improved early cognitive and overall neurologic function, whereas in protocol 2 there was no significant effect on functional performance. CONCLUSIONS: Although Xe conferred functional neurologic improvement even when treatment was delayed for 1 hr, the early treatment with either Xe or Iso translated to only marginal functional improvement.
OBJECTIVE: Neurologic outcome after cardiopulmonary resuscitation from cardiac arrest carries a poor prognosis and treatment options to ameliorate brain damage are limited. DESIGN: Report of two protocols investigating the effects of xenon (Xe) and isoflurane (Iso) in a porcine model of prolonged cardiac arrest and subsequent cardiopulmonary resuscitation on functional neurologic outcomes. SETTING: Prospective, randomized, laboratory animal study. SUBJECTS: Male domestic pigs (Sus scrofa). INTERVENTIONS: After successful resuscitation from 8 mins of cardiac arrest and 5 mins of cardiopulmonary resuscitation, pigs were randomized to receive either Xe for 1 or 5 hrs in comparison with untreated controls 1 hr after cardiopulmonary resuscitation (protocol 1) or to receive Iso or Xe in comparison with untreated controls 10 mins after cardiopulmonary resuscitation (protocol 2). MEASUREMENTS AND MAIN RESULTS: Animals were exposed to an established cognitive function test and gross neurologic performance was assessed using a neurologic deficit score. In protocol 1, Xe administration resulted in improved early cognitive and overall neurologic function, whereas in protocol 2 there was no significant effect on functional performance. CONCLUSIONS: Although Xe conferred functional neurologic improvement even when treatment was delayed for 1 hr, the early treatment with either Xe or Iso translated to only marginal functional improvement.
Authors: Sarah Devroe; Jurgen Lemiere; Marc Van de Velde; Marc Gewillig; Derize Boshoff; Steffen Rex Journal: Trials Date: 2015-03-04 Impact factor: 2.279
Authors: Kei Hayashida; Santiago J Miyara; Koichiro Shinozaki; Ryosuke Takegawa; Tai Yin; Daniel M Rolston; Rishabh C Choudhary; Sara Guevara; Ernesto P Molmenti; Lance B Becker Journal: Front Med (Lausanne) Date: 2021-01-14
Authors: Matthias Derwall; Andreas Ebeling; Kay Wilhelm Nolte; Joachim Weis; Rolf Rossaint; Fumito Ichinose; Christoph Nix; Michael Fries; Anne Brücken Journal: Crit Care Date: 2015-09-15 Impact factor: 9.097