OBJECTIVE: To compare resuscitation outcomes and myocardial function among intra-arrest head cooling, delayed surface cooling, and uncooled controls. DESIGN: Prospective animal study. SETTING: University-affiliated animal research laboratory. SUBJECTS: Twenty-four male domestic pigs. INTERVENTIONS: Ventricular fibrillation remained untreated for 10 mins after which animals were assigned into three groups: 1) intra-arrest head cooling, 2) postresuscitation surface cooling, and 3) uncooled controls. Head cooling by evaporative perfluorochemical began coincident with the start of cardiopulmonary resuscitation and continued for a total of 4 hrs. Surface cooling using a cooling blanket began at 2 hrs after return of spontaneous circulation and continued for 8 hrs. Control animals were treated identically with the exception for cooling. MEASUREMENTS AND MAIN RESULTS: Return of spontaneous circulation was achieved in eight of eight head-cooled animals, in seven of eight surface-cooled animals, and in seven of eight of controls. Myocardial functions measured by transthoracic echocardiography were significantly better in the head-cooled animals than in surface-cooled and controls. All head-cooled animals survived for more than 96 hrs. This contrasted with six of eight survivors after surface cooling, and only two of eight among controls. CONCLUSIONS: Both intra-arrest head cooling and delayed surface cooling improved postresuscitation myocardial dysfunction. The beneficial effects were greatest with head cooling initiated with cardiopulmonary resuscitation.
OBJECTIVE: To compare resuscitation outcomes and myocardial function among intra-arrest head cooling, delayed surface cooling, and uncooled controls. DESIGN: Prospective animal study. SETTING: University-affiliated animal research laboratory. SUBJECTS: Twenty-four male domestic pigs. INTERVENTIONS:Ventricular fibrillation remained untreated for 10 mins after which animals were assigned into three groups: 1) intra-arrest head cooling, 2) postresuscitation surface cooling, and 3) uncooled controls. Head cooling by evaporative perfluorochemical began coincident with the start of cardiopulmonary resuscitation and continued for a total of 4 hrs. Surface cooling using a cooling blanket began at 2 hrs after return of spontaneous circulation and continued for 8 hrs. Control animals were treated identically with the exception for cooling. MEASUREMENTS AND MAIN RESULTS: Return of spontaneous circulation was achieved in eight of eight head-cooled animals, in seven of eight surface-cooled animals, and in seven of eight of controls. Myocardial functions measured by transthoracic echocardiography were significantly better in the head-cooled animals than in surface-cooled and controls. All head-cooled animals survived for more than 96 hrs. This contrasted with six of eight survivors after surface cooling, and only two of eight among controls. CONCLUSIONS: Both intra-arrest head cooling and delayed surface cooling improved postresuscitation myocardial dysfunction. The beneficial effects were greatest with head cooling initiated with cardiopulmonary resuscitation.
Authors: Mohammad Fazel Bakhsheshi; Errol E Stewart; Joo Ho Tai; Laura Morrison; Lynn Keenliside; Ting-Yim Lee Journal: Neurocrit Care Date: 2016-02 Impact factor: 3.210
Authors: M Chenoune; F Lidouren; C Adam; S Pons; L Darbera; P Bruneval; B Ghaleh; R Zini; J-L Dubois-Randé; P Carli; B Vivien; J-D Ricard; A Berdeaux; R Tissier Journal: Circulation Date: 2011-08-01 Impact factor: 29.690