Literature DB >> 20449334

Zinc(II)-catalyzed Grignard additions to ketones with RMgBr and RMgI.

Manabu Hatano1, Orie Ito, Shinji Suzuki, Kazuaki Ishihara.   

Abstract

Highly efficient alkylations and arylations of ketones with Grignard reagents (RMgBr and RMgI) have been developed using catalytic ZnCl(2), Me(3)SiCH(2)MgCl, and LiCl. Tertiary alcohols were obtained in high yields with high chemoselectivities, while minimizing undesired side products produced by reduction and enolization.

Entities:  

Year:  2010        PMID： 20449334     DOI： 10.1039/b926243a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  Main group multiple C-H/N-H bond activation of a diamine and isolation of a molecular dilithium zincate hydride: experimental and DFT evidence for alkali metal-zinc synergistic effects.

Authors:  Ross Campbell; Daniel Cannon; Pablo García-Álvarez; Alan R Kennedy; Robert E Mulvey; Stuart D Robertson; Jörg Sassmannshausen; Tell Tuttle
Journal:  J Am Chem Soc       Date:  2011-08-04       Impact factor: 15.419

2.  Nucleophilic arylation with tetraarylphosphonium salts.

Authors:  Zuyong Deng; Jin-Hong Lin; Ji-Chang Xiao
Journal:  Nat Commun       Date:  2016-01-29       Impact factor: 14.919
  2 in total

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