Controlled mineralization by extracellular matrix: monodisperse, colloidally stable calcium phosphate-hyaluronan hybrid nanospheres.

Uniform, monodisperse calcium phosphate nanospheres (40 nm) were prepared using a simple co-precipitation method via the segregation crystallization imposed by hyaluronan molecules. The nanospheres exhibit excellent colloidal/storage stability in water due to the incorporated extracellular substance.