Literature DB >> 20448663

PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity.

Sujit S Nair1, Binoj C Nair, Valerie Cortez, Dimple Chakravarty, Eric Metzger, Roland Schüle, Darrell W Brann, Rajeshwar R Tekmal, Ratna K Vadlamudi.   

Abstract

Histone methylation has a key role in oestrogen receptor (ERalpha)-mediated transactivation of genes. Proline glutamic acid and leucine-rich protein 1 (PELP1) is a new proto-oncogene that functions as an ERalpha co-regulator. In this study, we identified histone lysine demethylase, KDM1, as a new PELP1-interacting protein. These proteins, PELP1 and KDM1, were both recruited to ERalpha target genes, and PELP1 depletion affected the dimethyl histone modifications at ERalpha target genes. Dimethyl-modified histones H3K4 and H3K9 are recognized by PELP1, and PELP1 alters the substrate specificity of KDM1 from H3K4 to H3K9. Effective demethylation of dimethyl H3K9 by KDM1 requires a KDM1-ERalpha-PELP1 functional complex. These results suggest that PELP1 is a reader of H3 methylation marks and has a crucial role in modulating the histone code at the ERalpha target genes.

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Year:  2010        PMID： 20448663      PMCID： PMC2892318          DOI： 10.1038/embor.2010.62

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  15 in total

Review 1.  Histone acetyltransferases.

Authors:  S Y Roth; J M Denu; C D Allis
Journal:  Annu Rev Biochem       Date:  2001       Impact factor: 23.643

2.  Regulation of LSD1 histone demethylase activity by its associated factors.

Authors:  Yu-Jiang Shi; Caitlin Matson; Fei Lan; Shigeki Iwase; Tadashi Baba; Yang Shi
Journal:  Mol Cell       Date:  2005-09-16       Impact factor: 17.970

Review 3.  Chromatin modifications and their function.

Authors:  Tony Kouzarides
Journal:  Cell       Date:  2007-02-23       Impact factor: 41.582

4.  Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors.

Authors:  Ivan Garcia-Bassets; Young-Soo Kwon; Francesca Telese; Gratien G Prefontaine; Kasey R Hutt; Christine S Cheng; Bong-Gun Ju; Kenneth A Ohgi; Jianxun Wang; Laure Escoubet-Lozach; David W Rose; Christopher K Glass; Xiang-Dong Fu; Michael G Rosenfeld
Journal:  Cell       Date:  2007-02-09       Impact factor: 41.582

5.  Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha.

Authors:  R K Vadlamudi; R A Wang; A Mazumdar; Y Kim; J Shin; A Sahin; R Kumar
Journal:  J Biol Chem       Date:  2001-07-31       Impact factor: 5.157

Review 6.  Epigenetic regulation of nuclear steroid receptors.

Authors:  Jennifer E Leader; Chenguang Wang; Maofu Fu; Richard G Pestell
Journal:  Biochem Pharmacol       Date:  2006-07-17       Impact factor: 5.858

7.  Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.

Authors:  Yujiang Shi; Fei Lan; Caitlin Matson; Peter Mulligan; Johnathan R Whetstine; Philip A Cole; Robert A Casero; Yang Shi
Journal:  Cell       Date:  2004-12-29       Impact factor: 41.582

8.  An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation.

Authors:  Min Gyu Lee; Christopher Wynder; Neil Cooch; Ramin Shiekhattar
Journal:  Nature       Date:  2005-08-03       Impact factor: 49.962

9.  LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.

Authors:  Eric Metzger; Melanie Wissmann; Na Yin; Judith M Müller; Robert Schneider; Antoine H F M Peters; Thomas Günther; Reinhard Buettner; Roland Schüle
Journal:  Nature       Date:  2005-08-03       Impact factor: 49.962

Review 10.  Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR.

Authors:  Ratna K Vadlamudi; Rakesh Kumar
Journal:  Nucl Recept Signal       Date:  2007-05-17
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  55 in total

1.  Central role for PELP1 in nonandrogenic activation of the androgen receptor in prostate cancer.

Authors:  Lin Yang; Preethi Ravindranathan; Meera Ramanan; Payal Kapur; Stephen R Hammes; Jer-Tsong Hsieh; Ganesh V Raj
Journal:  Mol Endocrinol       Date:  2012-03-08

2.  Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.

Authors:  Pavlos Fanis; Nynke Gillemans; Ali Aghajanirefah; Farzin Pourfarzad; Jeroen Demmers; Fatemehsadat Esteghamat; Ratna K Vadlamudi; Frank Grosveld; Sjaak Philipsen; Thamar B van Dijk
Journal:  Mol Cell Proteomics       Date:  2012-08-07       Impact factor: 5.911

Review 3.  Minireview: Deciphering the Cellular Functions of PELP1.

Authors:  Preethi Ravindranathan; Carol A Lange; Ganesh V Raj
Journal:  Mol Endocrinol       Date:  2015-07-09

Review 4.  KDM1 class flavin-dependent protein lysine demethylases.

Authors:  Jonathan M Burg; Jennifer E Link; Brittany S Morgan; Frederick J Heller; Amanda E Hargrove; Dewey G McCafferty
Journal:  Biopolymers       Date:  2015-07       Impact factor: 2.505

5.  Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression.

Authors:  Bamaprasad Dutta; Yan Ren; Piliang Hao; Kae Hwan Sim; Esther Cheow; Sunil Adav; James P Tam; Siu Kwan Sze
Journal:  Mol Cell Proteomics       Date:  2014-05-15       Impact factor: 5.911

6.  The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1.

Authors:  Kristine M Hussey; Hongshan Chen; Christine Yang; Eugene Park; Nasun Hah; Hediye Erdjument-Bromage; Paul Tempst; Matthew J Gamble; W Lee Kraus
Journal:  Mol Cell Biol       Date:  2014-04-21       Impact factor: 4.272

7.  ERRα induces H3K9 demethylation by LSD1 to promote cell invasion.

Authors:  Julie Carnesecchi; Christelle Forcet; Ling Zhang; Violaine Tribollet; Bruno Barenton; Rafik Boudra; Catherine Cerutti; Isabelle M L Billas; Aurélien A Sérandour; Jason S Carroll; Claude Beaudoin; Jean-Marc Vanacker
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-27       Impact factor: 11.205

Review 8.  Readers of histone methylarginine marks.

Authors:  Sitaram Gayatri; Mark T Bedford
Journal:  Biochim Biophys Acta       Date:  2014-02-28

9.  Control of histone H3 lysine 9 (H3K9) methylation state via cooperative two-step demethylation by Jumonji domain containing 1A (JMJD1A) homodimer.

Authors:  Satoshi Goda; Takayuki Isagawa; Yoko Chikaoka; Takeshi Kawamura; Hiroyuki Aburatani
Journal:  J Biol Chem       Date:  2013-11-08       Impact factor: 5.157

10.  PELP1 oncogenic functions involve CARM1 regulation.

Authors:  Monica Mann; Valerie Cortez; Ratna Vadlamudi
Journal:  Carcinogenesis       Date:  2013-03-13       Impact factor: 4.944
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